Astrocyte activation and reactive gliosis

被引:1327
作者
Pekny, M [1 ]
Nilsson, M [1 ]
机构
[1] Univ Gothenburg, Sahlgrenska Acad, Inst Clin Neurosci, Arvid Carlsson Inst Neurosci, Gothenburg, Sweden
关键词
astrocytes; intermediate filaments; GFAP; vimentin; nestin; reactive gliosis (astrogliosis); astrocyte processes; CNS trauma; brain ischemia; CNS regeneration;
D O I
10.1002/glia.20207
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Astrocytes become activated (reactive) in response to many CNS pathologies, such as stroke, trauma, growth of a tumor, or neurodegenerative disease. The process of astrocyte activation remains rather enigmatic and results in so-called "reactive gliosis," a reaction with specific structural and functional characteristics. In stroke or in CNS trauma, the lesion itself, the ischemic environment, disrupted blood-brain barrier, the inflammatory response, as well as in metabolic, excitotoxic, and in some cases oxidative crises-all affect the extent and quality of reactive gliosis. The fact that astrocytes function as a syncytium of interconnected cells both in health and in disease, rather than as individual cells, adds yet another dimension to this picture. This review focuses on several aspects of astrocyte activation and reactive gliosis and discusses its possible roles in the CNS trauma and ischemia. Particular emphasis is placed on the lessons learnt from mouse genetic models in which the absence of intermediate filament proteins in astrocytes leads to attenuation of reactive gliosis with distinct pathophysiological and clinical consequences. (c) 2005 Wiley-Liss, Inc.
引用
收藏
页码:427 / 434
页数:8
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