Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation

被引：208

作者：

Hem, Stanley L. ^{[1
]}

HogenEsch, Harm

机构：

[1] Purdue Univ, Dept Ind & Phys Pharm, W Lafayette, IN 47907 USA

[2] Purdue Univ, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA

来源：

EXPERT REVIEW OF VACCINES | 2007年 / 6卷 / 05期

关键词：

adsorption mechanism; aluminum hydroxide adjuvant; aluminum phosphate adjuvant; antigen trapping; antigen uptake; dendritic cell maturation; isoelectric point; recruitment of antigen-presenting cells; t-cell activation; t-cell differentiation;

D O I：

10.1586/14760584.6.5.685

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aluminum-containing adjuvants are an important component of many vaccines because they safely potentiate the immune response. The structure and properties of aluminum hydroxide adjuvant, aluminum phosphate adjuvant and alum-precipitated adjuvants are presented in this review. The major antigen adsorption mechanisms, electrostatic attraction and ligand exchange, are related to the adjuvant structure. The manner by which aluminum-containing adjuvants potentiate the immune response is related to the structure, properties of the adjuvant and adsorption mechanism. Immunopotentiation occurs through the following sequential steps: inflammation and recruitment of antigen-presenting cells, retention of antigen at the injection site, uptake of antigen, dendritic cell maturation, T-cell activation and T-cell differentiation.

引用

页码：685 / 698

页数：14