Pineal-specific agouti protein regulates teleost background adaptation

被引:58
作者
Zhang, Chao [1 ]
Song, Youngsup [2 ]
Thompson, Darren A. [3 ]
Madonna, Michael A. [3 ]
Millhauser, Glenn L. [3 ]
Toro, Sabrina [4 ]
Varga, Zoltan [4 ]
Westerfield, Monte [4 ]
Gamse, Joshua [5 ]
Chen, Wenbiao [1 ]
Cone, Roger D. [1 ]
机构
[1] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA
[2] Salk Inst Biol Sci, La Jolla, CA 92037 USA
[3] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA
[4] Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA
[5] Vanderbilt Univ, Med Ctr, Dept Biol Sci, Nashville, TN 37232 USA
基金
美国国家卫生研究院;
关键词
pigmentation; camouflage; zebrafish; MELANOCYTE-STIMULATING-HORMONE; MELANIN-CONCENTRATING HORMONE; MELANOCORTIN RECEPTORS; GENE-EXPRESSION; FLOATING HEAD; NON-CONE; NON-ROD; ZEBRAFISH; MELANOPSIN; EVOLUTION;
D O I
10.1073/pnas.1014941107
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background adaptation is used by teleosts as one of a variety of camouflage mechanisms for avoidance of predation. Background adaptation is known to involve light sensing by the retina and subsequent regulation of melanophore dispersion or contraction in melanocytes, mediated by alpha-melanocyte-stimulating hormone and melanin-concentrating hormone, respectively. Here, we demonstrate that an agouti gene unique to teleosts, agrp2, is specifically expressed in the pineal and is required for up-regulation of hypothalamic pmch and pmchl mRNA and melanosome contraction in dermal melanocytes in response to a white background. floating head, a mutant with defective pineal development, exhibits defective up-regulation of mch mRNAs by white background, whereas nrc, a blind mutant, exhibits a normal response. These studies identify a role for the pineal in background adaptation in teleosts, a unique physiological function for the agouti family of proteins, and define a neuroendocrine axis by which environmental background regulates pigmentation.
引用
收藏
页码:20164 / 20171
页数:8
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