Obesity and breast cancer

被引：13

作者：

Mazur-Roszak, Malgorzata ^{[1
]}

Litwiniuk, Maria ^{[1
]}

Grodecka-Gazdecka, Sylwia ^{[1
]}

机构：

[1] Uniwersytet Med K Marcinkowskiego Poznaniu, Klin Onkol, Oddzial Chemioterapii, PL-61878 Poznan, Poland

来源：

WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY | 2010年 / 14卷 / 04期

关键词：

obesity; physical activity; breast cancer; BODY-MASS INDEX; GROWTH-FACTOR-I; PHYSICAL-ACTIVITY; INSULIN-RESISTANCE; PROSPECTIVE COHORT; LEPTIN EXPRESSION; RISK; WOMEN; WEIGHT; STAGE;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Obesity is described as pathological enlargement of adipose tissue. It causes metabolic disorders and organ failure and increases risk of many kinds of cancers. BMI > 25 mg/m2 and low physical activity are associated with breast cancer pathogenesis. Insulin represents a major link between obesity and breast cancer; it not only participates in metabolic changes, but is also a well known mitogen. Adipocytes secrete leptin and adiponectin, which are important risk factors for breast cancer. Obese women show high leptin and low adiponectin levels. Decreased adiponectin level correlates with breast cancer risk. Obese patients tend to have non-palpable tumours, that can delay breast cancer diagnosis and worsen treatment prognosis. Therefore it is necessary to educate patients how to change their lifestyle, including adequate physical activity and diet.

引用

页码：270 / 275

页数：6

共 60 条

[21] Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women [J].

Gunter, Marc J. ;

Hoover, Donald R. ;

Yu, Herbert ;

Wassertheil-Smoller, Sylvia ;

Rohan, Thomas E. ;

Manson, JoAnn E. ;

Li, Jixin ;

Ho, Gloria Y. F. ;

Xue, Xiaonan ;

Anderson, Garnet L. ;

Kaplan, Robert C. ;

Harris, Tiffany G. ;

Howard, Barbara V. ;

Wylie-Rosett, Judith ;

Burk, Robert D. ;

Strickler, Howard D. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2009, 101 (01) :48-60

[22]

Hjartåker A, 2008, ADV EXP MED BIOL, V630, P72

[23] Physical activity and survival after breast cancer diagnosis [J].

Holmes, MD ;

Chen, WY ;

Feskanich, D ;

Kroenke, CH ;

Colditz, GA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 293 (20) :2479-2486

[24] Adipocytokines and breast cancer risk [J].

Hou Wei-kai ;

Xu Yu-xin ;

Yu Ting ;

Zhang Li ;

Zhang Wen-wen ;

Fu Chun-li ;

Sun Yu ;

Wu Qing ;

Chen Li .

CHINESE MEDICAL JOURNAL, 2007, 120 (18) :1592-1596

[25] Dual effects of weight and weight gain on breast cancer risk [J].

Huang, ZP ;

Hankinson, SE ;

Colditz, GA ;

Stampfer, MJ ;

Hunter, DJ ;

Manson, JE ;

Hennekens, CH ;

Rosner, B ;

Speizer, FE ;

Willett, WC .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (17) :1407-1411

[26] Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells [J].

Jackson, JG ;

White, MF ;

Yee, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (16) :9994-10003

[27] Body mass index and cancer risk in Korean men and women [J].

Jee, Sun Ha ;

Yun, Ji Eun ;

Park, Eun Jung ;

Cho, Eo Rin ;

Park, Il Su ;

Sull, Jae Woong ;

Ohrr, Heechoul ;

Samet, Jonathan M. .

INTERNATIONAL JOURNAL OF CANCER, 2008, 123 (08) :1892-1896

[28] Tissue levels of adiponectin in breast cancer patients [J].

Karaduman, Mehmet ;

Bilici, Ahmet ;

Ozet, Ahmet ;

Sengul, Ali ;

Musabak, Ugur ;

Alomeroglu, Melih .

MEDICAL ONCOLOGY, 2007, 24 (04) :361-366

[29]

Lee I., 2006, CANC EPIDEMIOLOGY PR, V3rd

[30] Relationship between obesity and pathologic response to neoadjuvant chemotherapy among women with operable breast cancer [J].

Litton, Jennifer K. ;

Gonzalez-Angulo, Ana M. ;

Warneke, Carla L. ;

Buzdar, Aman U. ;

Kau, Shu-Wan ;

Bondy, Melissa ;

Mahabir, Somdat ;

Hortobagyi, Gabriel N. ;

Brewster, Abenaa M. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (25) :4072-4077

← 1 2 3 4 5 6 →