Anti-varicella-zoster virus bicyclic nucleosides: replacement of furo by pyrro base reduces antiviral potency

被引：21

作者：

McGuigan, C

Pathirana, RN

Jones, G

Andrei, G

Snoeck, R

De Clercq, E

Balzarini, J

机构：

[1] Cardiff Univ, Welsh Sch Pharm, Cardiff CF10 3XF, S Glam, Wales

[2] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 2000年 / 11卷 / 05期

关键词：

varicella-zoster virus; bicyclic nucleosides; zoster; shingles; nucleoside analogues;

D O I：

10.1177/095632020001100505

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have recently reported the discovery of an entirely new category of potent antiviral agents based on novel deoxynucleoside analogues with unusual fluorescent bicyclic furo base moieties. To probe structure-activity relationships and to seek to optimize the properties of the lead compounds, we prepared pyrro analogues of the furo systems. We herein report the synthesis, characterization and antiviral evaluation of these novel compounds.

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页码：343 / 348

页数：6

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