Gene diversity of chimpanzee ABO blood group genes elucidated from exon 7 sequences

被引：7

作者：

Sumiyama, K

Kitano, T

Noda, R

Ferrell, RE

Saitou, N ^{[1
]}

机构：

[1] Natl Inst Genet, Lab Evolutionary Genet, Mishima, Shizuoka 4118540, Japan

[2] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15261 USA

来源：

GENE | 2000年 / 259卷 / 1-2期

关键词：

glycosyltransferases; hominoids; nucleotide diversity; phylogenetic network;

D O I：

10.1016/S0378-1119(00)00440-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Human and non-human primate ABO blood group genes show relatively large numbers of nucleotide differences. In this study, we determined exon 7 sequences for 10 individuals of common chimpanzee and for four individuals of bonobo to estimate nucleotide diversities among them. Sequence data showed the existence of chimpanzee specific 9-base deletion in the beginning of the exon 7 coding region. From a phylogenetic network of exon 7 sequences of ABO blood group genes for human, common chimpanzee, bonobo and gorilla, effects of parallel substitutions and/or some kinds of convergent events are inferred in the chimpanzee lineage. We also estimated nucleotide diversities for common chimpanzee and bonobo ABO blood group genes, and these values were 0.4% and 0.2%, respectively. These values are higher than that of most human genes. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：75 / 79

页数：5

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