Chest vibration redistributes intra-airway CO2 during tracheal insufflation in ventilatory failure

Objective: To determine if high-frequency external chest wall vibration added to low flow intratracheal fresh gas insufflation alters the intra-airway CO2 distribution and the resistance to CO2 transport from the lungs. Design: Prospective study. Setting: Experimental laboratory. Subjects: Six adult anesthetized and paralyzed mongrel dogs (mean weight 24.3 +/- 4.4 kg). Interventions: Dogs were ventilated by three methods: a) intermittent positive pressure ventilation; b) intermittent positive pressure ventilation with tracheal insufflation of fresh gas (FlO(2) of 0.4) flowing at 0.15 L/kg/min through a catheter positioned at the carina; and c) intermittent positive pressure ventilation with tracheal insufflation and with external high-frequency chest wall vibration of the dependent hemithorax. Measurements and Main Results: We measured arterial blood gas values as an index of global gas exchange, and intrapulmonary airway CO2 concentrations as an index of local gas exchange, Intra-airway CO2 concentrations along the axis of the airways were measured via a sampling catheter, Airway axial concentration profiles were constructed and resistances to gas transport were calculated from the measured data, Vibration increased intraluminal CO2 concentrations from 1.1% to 2.5% mouthward of the insufflation catheter tip, Peak resistance to CO2 transport decreased by 65% during vibration relative to the insufflation only value. Vibration displaced peak transport resistance from second- to fourth-generation airways. Conclusions: Global gas exchange improves during ventilation by chest wall vibration with low flow insufflation, Local gas exchange in the central airways is also improved due to increased intraluminal mixing and CO2 elimination. This ventilation technique may confer therapeutic advantages over conventional mechanical ventilation in the treatment of ventilatory failure.