Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength

被引：140

作者：

Ammann, Patrick ^{[1
]}

Badoud, Isabelle ^{[1
]}

Barraud, Sebastien ^{[1
]}

Dayer, Romain ^{[1
]}

Rizzoli, Rene ^{[1
]}

机构：

[1] Univ Hosp, Dept Rehabil & Geriatr, Div Bone Dis, WHO Collaborating Ctr Osteoporosis Prevent, CH-1211 Geneva 14, Switzerland

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 09期

关键词：

strontium ranelate; osteoporosis; biomechanics; bone quality; nanoindentation;

D O I：

10.1359/jbmr.070607

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Beside its influence on determinants of bone strength (geometry, microarchitecture), which is likely to be related to a cellular effect, strontium ranelate improves bone tissue quality as evaluated by nanoindentation, increasing elastic modulus, hardness, and dissipated energy in vertebrae of rats treated for 104 wk with daily dose from 0 to 900 mg/kg.

引用

页码：1419 / 1425

页数：7

共 28 条

[1] Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats
Ammann, P
Shen, V
Robin, B
Mauras, Y
Bonjour, JP
Rizzoli, R
[J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 (12) : 2012 - 2020
[2] Bone density and shape as determinants of bone strength in IGF-I and/or pamidronate-treated ovariectomized rats
Ammann, P
Rizzoli, R
Meyer, JM
Bonjour, JP
[J]. OSTEOPOROSIS INTERNATIONAL, 1996, 6 (03) : 219 - 227
[3] Protein undernutrition-induced bone loss is associated with decreased IGF-I levels and estrogen deficiency
Ammann, P
Bourrin, S
Bonjour, JP
Meyer, JM
Rizzoli, R
[J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2000, 15 (04) : 683 - 690
[4] Dietary essential amino acid supplements increase bone strength by influencing bone mass and bone microarchitecture in ovariectomized adult rats fed an isocaloric low-protein diet
Ammann, P
Laib, A
Bonjour, JP
Meyer, JM
Rüegsegger, P
Rizzoli, R
[J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (07) : 1264 - 1272
[5] AMMANN P, 1998, OSTEOPOROSIS DIAGNOS, P257
[6] In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation
Baron, R
Tsouderos, Y
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 450 (01) : 11 - 17
[7] Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis)
Buehler, J
Chappuis, P
Saffar, JL
Tsouderos, Y
Vignery, A
[J]. BONE, 2001, 29 (02) : 176 - 179
[8] Microfractures and microcracks in subchondral bone: are they relevant to osteoarthrosis?
Burr, DB
Radin, EL
[J]. RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2003, 29 (04) : 675 - +
[9] The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro
Canalis, E
Hott, M
Deloffre, P
Tsouderos, Y
Marie, PJ
[J]. BONE, 1996, 18 (06) : 517 - 523
[10] Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice
Delannoy, P
Bazot, D
Marie, PJ
[J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2002, 51 (07): : 906 - 911

← 1 2 3 →