Lessons in estrogen biology from knockout and transgenic animals

被引：223

作者：

Hewitt, SC ^{[1
]}

Harrell, JC ^{[1
]}

Korach, KS ^{[1
]}

机构：

[1] NIEHS, Receptor Biol Sect, Reprod & Dev Toxicol Lab, Res Triangle Pk, NC 27709 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY | 2005年 / 67卷

关键词：

estrogen receptor; mammary gland; uterus; estrogen mechanisms;

D O I：

10.1146/annurev.physiol.67.040403.115914

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Tremendous progress has been made in elucidating numerous critical aspects of estrogen signaling. New tools and techniques have enabled detailed molecular analysis of components that direct estrogen responses. At the other end of the spectrum, generation of a multiplicity of transgenic animals has allowed analysis of the physiological roles of the estrogen-signaling components in biologically relevant models. Here, we review the ever-increasing body of knowledge in the field of estrogen biology, especially as applied to the female reproductive processes.

引用

页码：285 / 308

页数：26

共 94 条

[31]

Griffith JS, 1997, AM J PATHOL, V150, P2223

[32] Different regulatory pathways of endometrial connexin expression:: Preimplantation hormonal-mediated pathway versus embryo implantation-initiated pathway [J].

Grümmer, R ;

Hewitt, SW ;

Traub, O ;

Korach, KS ;

Winterhager, E .

BIOLOGY OF REPRODUCTION, 2004, 71 (01) :273-281

[33] Nuclear receptor coregulators: multiple modes of modification [J].

Hermanson, O ;

Glass, CK ;

Rosenfeld, MG .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2002, 13 (02) :55-60

[34]

Hewitt SC, 2002, BIOL REPROD, V67, P1268, DOI [10.1095/biolreprod67.4.1268, 10.1095/biolreprod.102.002436]

[35] Estrogen receptor-dependent genomic responses in the uterus mirror the biphasic physiological response to estrogen [J].

Hewitt, SC ;

Deroo, BJ ;

Hansen, K ;

Collins, J ;

Grissom, S ;

Afshari, CA ;

Korach, KS .

MOLECULAR ENDOCRINOLOGY, 2003, 17 (10) :2070-2083

[36]

Hewitt SC, 2002, CANCER RES, V62, P2798

[37] Estrogen receptors: Structure, mechanisms and function [J].

Hewitt S.C. ;

Korach K.S. .

Reviews in Endocrine and Metabolic Disorders, 2002, 3 (3) :193-200

[38] COUPLING OF DUAL SIGNALING PATHWAYS - EPIDERMAL GROWTH-FACTOR ACTION INVOLVES THE ESTROGEN-RECEPTOR [J].

IGNARTROWBRIDGE, DM ;

NELSON, KG ;

BIDWELL, MC ;

CURTIS, SW ;

WASHBURN, TF ;

MCLACHLAN, JA ;

KORACH, KS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4658-4662

[39] Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol [J].

IgnarTrowbridge, DM ;

Pimentel, M ;

Parker, MG ;

McLachlan, JA ;

Korach, KS .

ENDOCRINOLOGY, 1996, 137 (05) :1735-1744

[40] PEPTIDE GROWTH-FACTORS ELICIT ESTROGEN RECEPTOR-DEPENDENT TRANSCRIPTIONAL ACTIVATION OF AN ESTROGEN-RESPONSIVE ELEMENT [J].

IGNARTROWBRIDGE, DM ;

TENG, CT ;

ROSS, KA ;

PARKER, MG ;

KORACH, KS ;

MCLACHLAN, JA .

MOLECULAR ENDOCRINOLOGY, 1993, 7 (08) :992-998

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