Role of nitric oxide in hepatic ischemia-reperfusion injury

被引：112

作者：

Siriussawakul, Arunotai ^{[1
,2
]}

Zaky, Ahmed ^{[1
,2
]}

Lang, John D. ^{[1
,2
]}

机构：

[1] Univ Washington, Sch Med, Dept Anesthesiol & Pain Med, Seattle, WA 98108 USA

[2] Univ Washington, Sch Med, VA Puget Sound Healthcare Syst, Seattle, WA 98108 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 48期

关键词：

Nitric oxide; Liver; Ischemia-reperfusion injury; Drug delivery; ORTHOTOPIC LIVER-TRANSPLANTATION; NF-KAPPA-B; ISCHEMIA/REPERFUSION INJURY; S-NITROSYLATION; RAT-LIVER; SUPEROXIDE; APOPTOSIS; PROTECTS; SYNTHASE; ACTIVATION;

D O I：

10.3748/wjg.v16.i48.6079

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Hepatic ischemia-reperfusion injury (IRI) occurs upon restoration of hepatic blood flow after a period of ischemia. Decreased endogenous nitric oxide (NO) production resulting in capillary luminal narrowing is central in the pathogenesis of IRI. Exogenous NO has emerged as a potential therapy for IRI based on its role in decreasing oxidative stress, cytokine release, leukocyte endothelial-adhesion and hepatic apoptosis. This review will highlight the influence of endogenous NO on hepatic IRI, role of inhaled NO in ameliorating IRI, modes of delivery, donor drugs and potential side effects of exogenous NO. (C) 2010 Baishideng. All rights reserved.

引用

页码：6079 / 6086

页数：8

共 54 条

[1]

Novel nitric oxide donor (FK409) ameliorates liver damage during extended liver resection with warm ischemia in dogs [J].