Telomeres - Bumps on the road to immortality

被引：27

作者：

Weinberg, RA ^{[1
]}

机构：

[1] MIT, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02142 USA

来源：

NATURE | 1998年 / 396卷 / 6706期

关键词：

D O I：

10.1038/23825

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Each time they divide cells lose their telomeres, the specialized structures at the end of chromosomes, leading to senescence and death. By expressing telomerase, an enzyme that repairs telomeres but is not usually found in adults, cells were thought to become immortalized. But a new study shows that things are not so simple, in certain types of epithelial cell at least, where inactivation of the p16/retinoblastoma pathway is also needed.

引用

页码：23 / 24

页数：2

共 9 条

[1] Extension of life-span by introduction of telomerase into normal human cells [J].

Bodnar, AG ;

Ouellette, M ;

Frolkis, M ;

Holt, SE ;

Chiu, CP ;

Morin, GB ;

Harley, CB ;

Shay, JW ;

Lichtsteiner, S ;

Wright, WE .

SCIENCE, 1998, 279 (5349) :349-352

[2] The expanding role of cell cycle regulators [J].

Jacks, T ;

Weinberg, RA .

SCIENCE, 1998, 280 (5366) :1035-1036

[3] Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells [J].

Kiyono, T ;

Foster, SA ;

Koop, JI ;

McDougall, JK ;

Galloway, DA ;

Klingelhutz, AJ .

NATURE, 1998, 396 (6706) :84-88

[4] Telomerase activation by the E6 gene product of human papillomavirus type 16 [J].

Klingelhutz, AJ ;

Foster, SA ;

McDougall, JK .

NATURE, 1996, 380 (6569) :79-82

[5] Can ends justify the means? Telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells [J].

Sedivy, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) :9078-9081

[6] Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a) [J].

Serrano, M ;

Lin, AW ;

McCurrach, ME ;

Beach, D ;

Lowe, SW .

CELL, 1997, 88 (05) :593-602

[7] Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span [J].

Vaziri, H ;

Benchimol, S .

CURRENT BIOLOGY, 1998, 8 (05) :279-282

[8] Myc activates telomerase [J].

Wang, J ;

Xie, LY ;

Allan, S ;

Beach, D ;

Hannon, GJ .

GENES & DEVELOPMENT, 1998, 12 (12) :1769-1774

[9] THE 2-STAGE MECHANISM CONTROLLING CELLULAR SENESCENCE AND IMMORTALIZATION [J].

WRIGHT, WE ;

SHAY, JW .

EXPERIMENTAL GERONTOLOGY, 1992, 27 (04) :383-389

← 1 →