Synthesis and in vitro cytotoxic evaluation of new derivatives of pyrido[1,2-a]benzimidazolic ring system:: The pyrido[1′,2′:1,2]imidazo[4,5-h]quinazolines

被引：39

作者：

Dupuy, M

Pinguet, F

Chavignon, O

Chezal, JM

Teulade, JC

Chapat, JP

Blache, Y

机构：

[1] Fac Pharm Montpellier, Lab Chim Organ Pharmaceut, F-34060 Montpellier, France

[2] Ctr Reg Lutte Canc, Lab Oncopharmacol, F-34298 Montpellier 05, France

[3] UFR Pharm, Lab Chim Organ Pharmaceut, F-63001 Clermont Ferrand, France

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 09期

关键词：

pyrido[1 ',2 ': 1,2]imidazo[4,5-h]quinazoline; anticancer agent; multidrug resistance;

D O I：

10.1248/cpb.49.1061

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Access to the original series of pyrido[1 ' ,2 ' :1,2]imidazo[4,5-h]quinazoline was developed from a 1,3-dicarbonyl unit with some "N-C-N" bisnucleophilic reagents and the derivatives obtained were evaluated for in vitro cytotoxic activities against HL60 and A2780 cells. All compounds exhibited cytotoxic activities on resistant cell lines (MDR+; HL60R and A2780R) with no resistance phenomena.

引用

页码：1061 / 1065

页数：5

共 17 条

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