Cytokines in multiple sclerosis: pro-inflammation or pro-remyelination?

被引：13

作者：

Sharief, MK ^{[1
]}

机构：

[1] United Med & Dent Sch Guys & St Thomas Hosp, Guys Hosp, Dept Neurol, London SE1 9RT, England

来源：

MULTIPLE SCLEROSIS | 1998年 / 4卷 / 03期

关键词：

oligodendrocytes; remyelination; demyelination; cytokines;

D O I：

10.1177/135245859800400315

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The targets of the inflammatory response in multiple sclerosis (MS) ore myelin and the myelin producing cells, oligodendrocytes. The infiltration of activated immune cells and recruitment of endogenous glio lead to the destruction of myelin and oligodendrocytes, a process that is compounded by the release of cytokines by infiltrating cells. Recent evidence suggests that key cytokines that are responsible for the destruction of myelin may also mediate the process of remyelination and repair It appears that both inflammatory and repair processes are governed by the temporal and spatial relation of cytokines to their targets.

引用

页码：169 / 173

页数：5

共 35 条

[1] OLIGODENDROCYTE LYSIS BY CD4(+) T-CELLS INDEPENDENT OF TUMOR-NECROSIS-FACTOR [J].

ANTEL, JP ;

WILLIAMS, K ;

BLAIN, M ;

MCREA, E ;

MCLAURIN, JA .

ANNALS OF NEUROLOGY, 1994, 35 (03) :341-348

[2] CYTOKINE LOCALIZATION IN MULTIPLE-SCLEROSIS LESIONS - CORRELATION WITH ADHESION MOLECULE EXPRESSION AND REACTIVE NITROGEN SPECIES [J].

BROSNAN, CF ;

CANNELLA, B ;

BATTISTINI, L ;

RAINE, CS .

NEUROLOGY, 1995, 45 (06) :S16-S21

[3] Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors [J].

Bruce, AJ ;

Boling, W ;

Kindy, MS ;

Peschon, J ;

Kraemer, PJ ;

Carpenter, MK ;

Holtsberg, FW ;

Mattson, MP .

NATURE MEDICINE, 1996, 2 (07) :788-794

[4] TUMOR NECROSIS FACTORS PROTECT NEURONS AGAINST METABOLIC EXCITOTOXIC INSULTS AND PROMOTE MAINTENANCE OF CALCIUM HOMEOSTASIS [J].

CHENG, B ;

CHRISTAKOS, S ;

MATTSON, MP .

NEURON, 1994, 12 (01) :139-153

[5]

Diab A, 1997, J NEUROPATH EXP NEUR, V56, P641

[6] gamma delta T-cell human glial cell interactions .1. In vitro induction of gamma delta T-cell expansion by human glial cells [J].

Freedman, MS ;

DSouza, S ;

Antel, JP .

JOURNAL OF NEUROIMMUNOLOGY, 1997, 74 (1-2) :135-142

[7] Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme-mediated apoptosis [J].

Friedlander, RM ;

Gagliardini, V ;

Rotello, RJ ;

Yuan, JY .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :717-724

[8]

HARTUNG HP, 1995, NEUROLOGY, V45, P22

[9] NITRIC-OXIDE MODULATES GAMMA-INTERFERON-INDUCED MHC CLASS-II ANTIGEN EXPRESSION ON RAT ASTROCYTES [J].

HEUSCHLING, P .

JOURNAL OF NEUROIMMUNOLOGY, 1995, 57 (1-2) :63-69

[10] TUMOR NECROSIS FACTOR IDENTIFIED IN MULTIPLE-SCLEROSIS BRAIN [J].

HOFMAN, FM ;

HINTON, DR ;

JOHNSON, K ;

MERRILL, JE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (02) :607-612

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