Intelligent crew-cut aggregates formed by thermosensitive block copolymers and their multiple morphologies

被引：22

作者：

Chen, XR ^{[1
]}

Ding, XB ^{[1
]}

Zheng, ZH ^{[1
]}

Peng, YX ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China

来源：

MACROMOLECULAR BIOSCIENCE | 2005年 / 5卷 / 02期

关键词：

block copolymer; morphologies; self-assembly; thermosensitive;

D O I：

10.1002/mabi.200400150

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The thermosensitive block copolymer poly(2-cinnamoylethyl methacrylate)-block-poly(N-isopropylacrylamide) (PCEMA-b-PNIPAAm) can form crew-cut aggregates with multiple morphologies under various micellization conditions. Spherical, rod-like, vesicular, lamellar aggregates, and large compound micelles were obtained from the block copolymers. The effects of different conditions, such as the copolymer composition, the nature of the common solvent, the initial copolymer concentrations, and the water content on the morphologies of the aggregates were studied in detail. The thermosensitive property of the aggregates was investigated through measuring the change of the dimension of the aggregates with changing the external temperature.

引用

页码：157 / 163

页数：7

共 20 条

[1] Thermo-responsive polymer nanoparticles with a core-shell micelle structure as site-specific drug carriers [J].

Cammas, S ;

Suzuki, K ;

Sone, C ;

Sakurai, Y ;

Kataoka, K ;

Okano, T .

JOURNAL OF CONTROLLED RELEASE, 1997, 48 (2-3) :157-164

[2] A self-assembly approach to temperature-responsive polymer nanocontainers [J].

Chen, XR ;

Ding, XB ;

Zheng, ZH ;

Peng, YX .

MACROMOLECULAR RAPID COMMUNICATIONS, 2004, 25 (17) :1575-1578

[3] Effects of temperature on diblock copolymer micelle composed of poly(γ-benzyl L-glutamate) and poly(N-isopropylacrylamide) [J].

Cheon, JB ;

Jeong, YI ;

Cho, CS .

POLYMER, 1999, 40 (08) :2041-2050

[4] Single-solvent preparation of crew-cut aggregates of various morphologies from an amphiphilic diblock copolymer [J].

Desbaumes, L ;

Eisenberg, A .

LANGMUIR, 1999, 15 (01) :36-38

[5] Thermodynamic size control of block copolymer vesicles in solution [J].

Luo, LB ;

Eisenberg, A .

LANGMUIR, 2001, 17 (22) :6804-6811

[6] Novel bowl-shaped morphology of crew-cut aggregates from Amphiphilic block copolymers of styrene and 5-(N,N-diethylamino)isoprene [J].

Riegel, IC ;

Eisenberg, A ;

Petzhold, CL ;

Samios, D .

LANGMUIR, 2002, 18 (08) :3358-3363

[7] Multiple pH-induced morphological changes in aggregates of polystyrene-block-poly(4-vinylpyridine) in DMF/H2O mixtures [J].

Shen, HW ;

Zhang, LF ;

Eisenberg, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (12) :2728-2740

[8] Multiple morphologies formed from an amphiphilic ABC triblock copolymer in solution [J].

Yu, GE ;

Eisenberg, A .

MACROMOLECULES, 1998, 31 (16) :5546-5549

[9] Novel morphologies of ''crew-cut'' aggregates of amphiphilic diblock copolymers in dilute solution [J].

Yu, K ;

Zhang, LF ;

Eisenberg, A .

LANGMUIR, 1996, 12 (25) :5980-5984

[10] Bilayer morphologies of self-assembled crew-cut aggregates of amphiphilic PS-b-PEO diblock copolymers in solution [J].

Yu, K ;

Eisenberg, A .

MACROMOLECULES, 1998, 31 (11) :3509-3518

← 1 2 →