How can proteolipids be central players in membrane fusion?

被引：34

作者：

Zimmerberg, J ^{[1
]}

机构：

[1] NICHHD, Lab Cellular & Mol Biophys, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0962-8924(01)02003-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proton transport ATPases have been celebrated as rotating motors that energize membranes. Now studies of membrane fusion in yeast suggest that the hydrophobic subunits of the vacuolar ATPase participate in formation of fusion pores. This work confirms previous studies showing that membrane approximation by alpha -helical protein bundles is inadequate for complete intracellular fusion and reopens a debate over whether the core of the central intermediate of membrane fusion is lipidic or proteinaceous.

引用

页码：233 / 235

页数：3

共 30 条

[1] Stepping rotation of F1-ATPase visualized through angle-resolved single-fluorophore imaging [J].

Adachi, K ;

Yasuda, R ;

Noji, H ;

Itoh, H ;

Harada, Y ;

Yoshida, M ;

Kinosita, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (13) :7243-7247

[2] Flickering fusion pores comparable with initial exocytotic pores occur in protein-free phospholipid bilayers [J].

Chanturiya, A ;

Chernomordik, LV ;

Zimmerberg, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (26) :14423-14428

[3] SNARE complex formation is triggered by Ca2+ and drives membrane fusion [J].

Chen, YA ;

Scales, SJ ;

Patel, SM ;

Doung, YC ;

Scheller, RH .

CELL, 1999, 97 (02) :165-174

[4] Snare-mediated membrane fusion [J].

Chen, YA ;

Scheller, RH .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (02) :98-106

[5] An early stage of membrane fusion mediated by the low pH conformation of influenza hemagglutinin depends upon membrane lipids [J].

Chernomordik, LV ;

Leikina, E ;

Frolov, V ;

Bronk, P ;

Zimmerberg, J .

JOURNAL OF CELL BIOLOGY, 1997, 136 (01) :81-93

[6] Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex [J].

Conchon, S ;

Cao, XC ;

Barlow, C ;

Pelham, HRB .

EMBO JOURNAL, 1999, 18 (14) :3934-3946

[7] Neurotransmitter release at rapid synapses [J].

Dunant, Y ;

Israël, M .

BIOCHIMIE, 2000, 82 (04) :289-302

[8] Multiple local contact sites are induced by GPI-linked influenza hemagglutinin during hemifusion and flickering pore formation [J].

Frolov, VA ;

Cho, MS ;

Bronk, P ;

Reese, TS ;

Zimmerberg, J .

TRAFFIC, 2000, 1 (08) :622-630

[9] The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase [J].

Gomis-Rüth, FX ;

Moncalián, G ;

Pérez-Luque, R ;

González, A ;

Cabezón, E ;

de la Cruz, F ;

Coll, M .

NATURE, 2001, 409 (6820) :637-641

[10] Membrane fusion and exocytosis [J].

Jahn, R ;

Südhof, TC .

ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 :863-911

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