Selective Magnesiation or Zincation of Highly Functionalized Alkenes and Cycloalkenes Using 2,2,6,6-Tetramethylpiperidyl Bases

被引：60

作者：

Bresser, Tomke ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, Butenandtstr 5-13,Haus F, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 08期

基金：

欧洲研究理事会;

关键词：

magnesium; metalations; nitroalkenes; TMP bases; zinc; CENTER-DOT-LICL; CHEMOSELECTIVE MULTIPLE FUNCTIONALIZATION; DIRECTED ORTHO-METALATION; ORGANIC-SYNTHESIS; TMP-ZINCATE; AROMATICS; REAGENTS; ARENES; TMP2MG-CENTER-DOT-2LICL; HETEROAROMATICS;

D O I：

10.1002/anie.201006641

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Smooth and mild: Mg or Zn TMP bases (TMP=2,2,6,6-tetramethylpiperidyl) allow the smooth metalation of various types of polyfunctional unsaturated substrates. Several sensitive functional groups such as ester, nitro, or trifluoromethylcarbonyl groups are tolerated. The new Zn or Mg intermediates undergo acylation, allylation, or cross-coupling reactions in satisfactory yields. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1914 / 1917

页数：4

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