Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice

被引：338

作者：

Tsujinaka, T

Fujita, J

Ebisui, C

Yano, M

Kominami, E

Suzuki, K

Tanaka, K

Katsume, A

Ohsugi, Y

Shiozaki, H

Monden, M

机构：

[1] JUNTENDO UNIV, SCH MED, DEPT BIOCHEM, TOKYO 113, JAPAN

[2] UNIV TOKYO, INST MOLEC & CELLULAR BIOSCI, TOKYO 113, JAPAN

[3] UNIV TOKUSHIMA, INST ENZYME RES, TOKUSHIMA 770, JAPAN

[4] CHUGAI PHARMACEUT CO LTD, FUJI GOTEMBA RES LABS, GOTEMBA 412, JAPAN

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1996年 / 97卷 / 01期

关键词：

protein degradation; cathepsin; proteasomes; ubiquitin; calpain;

D O I：

10.1172/JCI118398

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The muscles of IL-6 transgenic mice suffer from atrophy. Experiments were carried out on these transgenic mice to elucidate activation of proteolytic systems in the gastrocnemius muscles and blockage of this activation by treatment with the anti-mouse IL-6 receptor (mIL-6R) antibody, Muscle atrophy observed in 16-wk-old transgenic mice was completely blocked by treatment with the mn-SR antibody. In association with muscle atrophy, enzymatic activities and mRNA levels of cathepsins (B and L) and mRNA levels of ubiquitins (poly- and mono-ubiquitins) increased, whereas the mRNA level of muscle-specific calpain (calpain 3) decreased. All these changes were completely eliminated by treatment with the mIL-6R antibody. This IL-6 receptor antibody could, therefore, be effective against muscle wasting in sepsis and cancer cachexia, where IL-S plays an important role.

引用

页码：244 / 249

页数：6

共 54 条

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