Highly alkyl-selective addition to ketones with magnesium ate complexes derived from Grignard reagents

被引：76

作者：

Hatano, M ^{[1
]}

Matsumura, T ^{[1
]}

Ishihara, K ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Engn, Chikusa Ku, Nagoya, Aichi 4648603, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 04期

关键词：

D O I：

10.1021/ol047685i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient alkyl-selective addition to ketones with magnesium ate complexes derived from Grignard reagents and alkyllithiums is described, The nucleophilicity of R in R3MgLi is remarkably increased compared to that of the original RU or RMgX, while the basicity of R3MgLi is decreased. Furthermore, a highly R-selective addition to ketones is demonstrated using RMe2MgLi in place of R3MgLi.

引用

页码：573 / 576

页数：4

共 27 条

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