The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation

被引：280

作者：

Zhang, Xiaoyu

Germann, Sophie

Blus, Bartlomiej J.

Khorasanizadeh, Sepideh

Gaudin, Valerie

Jacobsen, Steven E.

机构：

[1] INRA, Inst JP Bourgin, Biol Cellulaire Lab, F-78026 Versailles, France

[2] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA

[3] Univ Virginia Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

[4] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 09期

关键词：

D O I：

10.1038/nsmb1283

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polycomb proteins are required for maintenance of silent chromatin states via histone H3 Lys27 trimethylation ( H3K27me3) in animals, but homologs are not found in plant genomes. Using a DamID- chip method, we found that the Arabidopsis thaliana chromodomain- containing protein LHP1 colocalizes with H3K27me3 genome- wide. The LHP1 chromodomain also binds H3K27me3 with high affinity, suggesting that LHP1 has functions similar to those of Polycomb.

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页码：869 / 871

页数：3

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