Biological activity of serotonin conjugates from the seeds of Centaurea nigra

被引：46

作者：

Kumarasamy, Y

Middleton, M

Reid, RG

Nahar, L

Sarker, SD ^{[1
]}

机构：

[1] Robert Gordon Univ, Sch Pharm, Phytopharmaceut Res Lab, Aberdeen AB10 1FR, Scotland

[2] Univ Aberdeen, Jaap Lab, Dept Chem, Aberdeen AB24 3UE, Scotland

来源：

FITOTERAPIA | 2003年 / 74卷 / 06期

关键词：

Centaurea nigra; DPPH assay; antibacterial activity; brine shrimp lethality bioassay;

D O I：

10.1016/S0367-326X(03)00144-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two serotonin conjugates, N-(trans-p-coumaroyl)-serotonin (1) and N-(trans-feruloyl)serotonin (maoschamine, 2), isolated from the methanol extract of the seeds of Centaurea nigra, have been assessed for antibacterial and free radical scavenging activities. The general toxicity of 1 and 2 has also been determined by the brine shrimp lethality bioassay. (C) 2003 Elsevier B.V. All rights reserved.

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页码：609 / 612

页数：4

相关论文

共 12 条

[1]

[Anonymous], 2005, ANTIBIOTICS LAB MED

[2] Bioactivity of moschamindole from Centaurea moschata [J].

Kumarasamy, Y ;

Fergusson, ME ;

Nahar, L ;

Sarker, SD .

PHARMACEUTICAL BIOLOGY, 2002, 40 (04) :307-310

[3] BRINE SHRIMP - A CONVENIENT GENERAL BIOASSAY FOR ACTIVE-PLANT CONSTITUENTS [J].

MEYER, BN ;

FERRIGNI, NR ;

PUTNAM, JE ;

JACOBSEN, LB ;

NICHOLS, DE ;

MCLAUGHLIN, JL .

PLANTA MEDICA, 1982, 45 (01) :31-34

[4] Dibenzylbutyrolactone lignans and indole alkaloids from the seeds of Centaurea nigra (Asteraceae) [J].

Middleton, M ;

Cox, PJ ;

Jaspars, M ;

Kumarasamy, Y ;

Nahar, L ;

Reid, R ;

Sarker, SD .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2003, 31 (06) :653-656

[5] IN-VITRO EVALUATION OF THE ANTIMICROBIAL ACTIVITIES OF SELECTED LOZENGES [J].

RICHARDS, RME ;

XING, DKL .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1993, 82 (12) :1218-1220

[6] CONJUGATED SEROTONINS AND PHENOLIC CONSTITUENTS IN SAFFLOWER SEED (CARTHAMUS-TINCTORIUS L) [J].

SAKAMURA, S ;

TERAYAMA, Y ;

KAWAKATSU, S ;

ICHIHARA, A ;

SAITO, H .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1980, 44 (12) :2951-2954

[7] Moschamine, cis-moschamine, moschamindole and moschamindolol: Four novel indole alkaloids from Centaurea moschata [J].

Sarker, SD ;

Savchenko, T ;

Whiting, P ;

Sik, V ;

Dinan, LN .

NATURAL PRODUCT LETTERS, 1997, 9 (03) :189-199

[8] A SIMPLE SCREENING METHOD FOR ANTIOXIDANTS AND ISOLATION OF SEVERAL ANTIOXIDANTS PRODUCED BY MARINE-BACTERIA FROM FISH AND SHELLFISH [J].

TAKAO, T ;

KITATANI, F ;

WATANABE, N ;

YAGI, A ;

SAKATA, K .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1994, 58 (10) :1780-1783

[9]

*USDA ARS NAT GEN, 2002, USDA ARS GRIN DAT

[10] Antioxidative phenolic compounds from Japanese barnyard millet (Echinochloa utilis) grains [J].

Watanabe, M .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1999, 47 (11) :4500-4505