Novel antineoplastic agents with efficacy against multidrug resistant tumor cells

被引：63

作者：

Medina, JC ^{[1
]}

Shan, B ^{[1
]}

Beckmann, H ^{[1
]}

Farrell, RP ^{[1
]}

Clark, DL ^{[1
]}

Learned, RM ^{[1
]}

Roche, D ^{[1
]}

Li, A ^{[1
]}

Baichwal, V ^{[1
]}

Case, C ^{[1
]}

Baeuerle, PA ^{[1
]}

Rosen, T ^{[1
]}

Jaen, JC ^{[1
]}

机构：

[1] Tularik Inc, S San Francisco, CA 94080 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(98)00477-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of pentafluorobenzenesulfonamides has been shown to inhibit the growth of a variety of human tumor cell lines. Among the cell types against which these agents were evaluated were the multidrug resistant (MDR) cell lines MCF-7/ADR and P388/ADR. The cytotoxic activity of members of this series of compounds was not affected by the multidrug resistant pump in MCF-7/ADR or P388/ADR cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2653 / 2656

页数：4

共 7 条

[1] A NEW RAPID AND SIMPLE NONRADIOACTIVE ASSAY TO MONITOR AND DETERMINE THE PROLIFERATION OF LYMPHOCYTES - AN ALTERNATIVE TO [H-3] THYMIDINE INCORPORATION ASSAY
AHMED, SA
GOGAL, RM
WALSH, JE
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1994, 170 (02) : 211 - 224
[2] BIEDLER JL, 1970, CANCER RES, V30, P1174
[3] BIOCHEMISTRY OF MULTIDRUG-RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER
GOTTESMAN, MM
PASTAN, I
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1993, 62 : 385 - 427
[4] GREVER MR, 1992, SEMIN ONCOL, V19, P622
[5] FEASIBILITY OF A HIGH-FLUX ANTICANCER DRUG SCREEN USING A DIVERSE PANEL OF CULTURED HUMAN TUMOR-CELL LINES
MONKS, A
SCUDIERO, D
SKEHAN, P
SHOEMAKER, R
PAULL, K
VISTICA, D
HOSE, C
LANGLEY, J
CRONISE, P
VAIGROWOLFF, A
GRAYGOODRICH, M
CAMPBELL, H
MAYO, J
BOYD, M
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1991, 83 (11) : 757 - 766
[6] Syntheses and structure-activity relationships of taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III
Ojima, I
Slater, JC
Kuduk, SD
Takeuchi, CS
Gimi, RH
Sun, CM
Park, YH
Pera, P
Veith, JM
Bernacki, RJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (03) : 267 - 278
[7] STRUCTURE-ACTIVITY-RELATIONSHIPS OF ANTINEOPLASTIC AGENTS IN MULTIDRUG RESISTANCE
SELASSIE, CD
HANSCH, C
KHWAJA, TA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (07) : 1914 - 1919

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