Regioselective routes towards 14-hydroxyabietane diterpenes. A formal synthesis of immunosuppressant (-)-triptolide from (+)-abietic acid

被引：45

作者：

Alvarez-Manzaneda, Enrique ^{[1
]}

Chahboun, Rachid ^{[1
]}

Bentaleb, Faouzia ^{[1
]}

Alvarez, Esteban ^{[1
]}

Escobar, M. Angeles ^{[1
]}

Sad-Diki, Said ^{[1
]}

Cano, Maria Jose ^{[1
]}

Messouri, Ibtissam ^{[1
]}

机构：

[1] Univ Granada, Fac Ciencias, Inst Biotechnol, Dept Quim Organ, E-18071 Granada, Spain

来源：

TETRAHEDRON | 2007年 / 63卷 / 45期

关键词：

D O I：

10.1016/j.tet.2007.07.088

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Two procedures to introduce an oxygenated function into the C-14 of abietane diterpenes with complete regioselectivity have been developed. Utilizing these, the synthesis of the antileishmanial quinone (-)-12-deoxyroyleanone (1) and a formal synthesis of antitumour and immunosuppressant (-)-triptonide (7) and (-)-triptolide (8) from (+)-abietic acid (13) have been carried out. (c) 2007 Published by Elsevier Ltd.

引用

页码：11204 / 11212

页数：9

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