Structural features of U6 snRNA and dynamic interactions with other spliceosomal components leading to pre-mRNA splicing

被引：10

作者：

Forne, T ^{[1
]}

Labourier, E ^{[1
]}

Antoine, E ^{[1
]}

Rossi, F ^{[1
]}

Gallouzi, I ^{[1
]}

Cathala, G ^{[1
]}

Tazi, J ^{[1
]}

Brunel, C ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,INST MOL GENET,UMR 5535,CNRS,F-34033 MONTPELLIER 1,FRANCE

来源：

BIOCHIMIE | 1996年 / 78卷 / 06期

关键词：

U snRNAs; splicing; pre-messenger RNA; 3' end modifications of U6 snRNA;

D O I：

10.1016/0300-9084(96)84750-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the spliceosome, the pre-mRNA, U2 and U6 snRNAs fold into a catalytic structure exhibiting striking similarities with domain V and VI of group II introns. Building of this tripartite structure implies that an evolutionary conserved base pairing between U4 and U6 snRNAs should be disrupted to allow potentially U6 catalytic residue to interact with U2 snRNAs and the pre-mRNA. The steps leading to U4/U6 disruption have been recently discovered and have been shown to involve a modification of the 3' end of U6 snRNA and the hnRNP C protein.

引用

页码：436 / 442

页数：7

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