Lack of association of the apoE4 allele with hippocampal sclerosis dementia

被引：21

作者：

Troncoso, JC

Kawas, CH

Chang, CK

Folstein, MF

Hedreen, JC

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21205

[4] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

[5] JOHNS HOPKINS UNIV,SCH MED,NIA,CTR GERONTOL RES,BALTIMORE,MD 21205

[6] JOHNS HOPKINS UNIV,SCH MED,RUSH ALZHEIMERS DIS CTR,BALTIMORE,MD 21205

[7] MIT,CAMBRIDGE,MA 02139

来源：

NEUROSCIENCE LETTERS | 1996年 / 204卷 / 1-2期

关键词：

aging; Alzheimer's disease; frontal lobe dementia; neurodegeneration;

D O I：

10.1016/0304-3940(96)12331-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5%, similar to that of a control population and significantly different from the similar to 40% found in Alzheimer's disease (AD) (P < 0.001). These observations suggest that apoE4 is not a risk factor for HSD.

引用

页码：138 / 140

页数：3

共 24 条

[1] APOLIPOPROTEIN-E GENE IN DIFFUSE LEWY BODY DISEASE WITH OR WITHOUT COEXISTING ALZHEIMERS-DISEASE [J].