In vitro activity of posaconazole against clinical isolates of dermatophytes

被引：34

作者：

Barchiesi, F

Arzeni, D

Camiletti, V

Simonetti, O

Cellini, A

Offidani, AM

Scalise, G

机构：

[1] Univ Ancona, Ist Malattie Infettive & Med Pubbl, Azienda Ospedaliera Umberta I, I-60020 Ancona, Italy

[2] Univ Ancona, Dermatol Clin, I-60020 Ancona, Italy

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2001年 / 39卷 / 11期

关键词：

D O I：

10.1128/JCM.39.11.4208-4209.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A broth macrodilution method following the recommendations established by the National Committee for Clinical Laboratory Standards was used to compare the in vitro activity of posaconazole (PCZ) with that of itraconazole (ITC) against 30 clinical isolates of dermatophytes belonging to six different species. In terms of MICs, PCZ showed an activity equal to that of ITC. MICs of PCZ at which 50% (MIC50) and 90% (MIC90) of the isolates were inhibited were 0.5 and >4.0 mug/ml, respectively. The MIC50 and MIC90 of ITC were 1.0 and >4.0 mug/ml, respectively. However, PCZ showed a more potent fungicidal activity than that of ITC against isolates belonging to the genus Microsporum (P = 0.03). PCZ merits further investigation as a potentially useful agent for treatment of dermatophytosis.

引用

收藏

页码：4208 / 4209

页数：2

相关论文

共 11 条

[1]

[Anonymous], 2000, M38A NAT COMM CLIN L

[2] In vitro activities of the new antifungal triazole SCH 56592 against common and emerging yeast pathogens [J].

Barchiesi, F ;

Arzeni, D ;

Fothergill, AW ;

Di Francesco, LF ;

Caselli, F ;

Rinaldi, MG ;

Scalise, G .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (01) :226-229

[3] Multicenter evaluation of proposed standardized procedure for antifungal susceptibility testing of filamentous fungi [J].

EspinelIngroff, A ;

Bartlett, M ;

Bowden, R ;

Chin, NX ;

Cooper, C ;

Fothergill, A ;

McGinnis, MR ;

Menezes, P ;

Messer, SA ;

Nelson, PW ;

Odds, FC ;

Pasarell, L ;

Peter, J ;

Pfaller, MA ;

Rex, JH ;

Rinaldi, MG ;

Shankland, GS ;

Walsh, TJ ;

Weitzman, I .

JOURNAL OF CLINICAL MICROBIOLOGY, 1997, 35 (01) :139-143

[4]

Jessup CJ, 2000, J CLIN MICROBIOL, V38, P341

[5] RESULTS OF GERMAN MULTICENTER STUDY OF ANTIMICROBIAL SUSCEPTIBILITIES OF TRICHOPHYTON-RUBRUM AND TRICHOPHYTON-MENTAGROPHYTES STRAINS CAUSING TINEA UNGUIUM [J].

KORTING, HC ;

OLLERT, M ;

MEIGEL, W ;

MEINHOF, W ;

MENSING, H ;

NOLTING, S ;

SCHERWITZ, C .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (05) :1206-1208

[6]

Larone D.H., 1995, MED IMPORTANT FUNGI, V3rd

[7] Efficacy of SCH-56592 in a temporarily neutropenic murine model of invasive aspergillosis with an itraconazole-susceptible and an itraconazole-resistant isolate of Aspergillus fumigatus [J].

Oakley, KL ;

Morrissey, G ;

Denning, DW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (07) :1504-1507

[8] Fluorometric assessment of in vitro antidermatophytic activities of antimycotics based on their keratin-penetrating power [J].

Okeke, CN ;

Tsuboi, R ;

Kawai, M ;

Ogawa, H .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (02) :489-491

[9] Comparison of in vitro activities of voriconazole and five established antifungal agents against different species of dermatophytes using a broth macrodilution method [J].

Perea, S ;

Fothergill, AW ;

Sutton, DA ;

Rinaldi, MG .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (01) :385-388

[10] Activity of a new triazole, Sch 56592, compared with those of four other antifungal agents tested against clinical isolates of Candida spp and Saccharomyces cerevisiae [J].

Pfaller, MA ;

Messer, S ;

Jones, RN .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (02) :233-235