A CD74-dependent MHC class I endolysosomal cross-presentation pathway

被引：110

作者：

Basha, Genc ^{[1
,2
,3
]}

Omilusik, Kyla ^{[1
,2
,3
]}

Chavez-Steenbock, Ana ^{[1
,2
,3
]}

Reinicke, Anna T. ^{[1
,2
,3
]}

Lack, Nathan ^{[1
,2
,3
]}

Choi, Kyung Bok ^{[1
,2
,3
]}

Jefferies, Wilfred A. ^{[1
,2
,3
]}

机构：

[1] Univ British Columbia, Biomed Res Ctr, Michael Smith Labs, Ctr Blood Res,Brain Res Ctr,Dept Microbiol & Immu, Vancouver, BC V5Z 1M9, Canada

[2] Univ British Columbia, Dept Med Genet, Biomed Res Ctr, Michael Smith Labs,Ctr Blood Res,Brain Res Ctr, Vancouver, BC, Canada

[3] Univ British Columbia, Dept Zool, Biomed Res Ctr, Michael Smith Labs,Ctr Blood Res,Brain Res Ctr, Vancouver, BC, Canada

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 03期

基金：

加拿大健康研究院;

关键词：

INVARIANT CHAIN; DENDRITIC CELLS; ANTIGEN PRESENTATION; T-CELLS; EXOGENOUS ANTIGEN; MOLECULES; COMPLEX; GENERATION; EXPRESSION; CROSSPRESENTATION;

D O I：

10.1038/ni.2225

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune responses are initiated and primed by dendritic cells (DCs) that cross-present exogenous antigen. The chaperone CD74 (invariant chain) is thought to promote DC priming exclusively in the context of major histocompatibility complex (MHC) class II. However, we demonstrate here a CD74-dependent MHC class I cross-presentation pathway in DCs that had a major role in the generation of MHC class I-restricted, cytolytic T lymphocyte (CTL) responses to viral protein- and cell-associated antigens. CD74 associated with MHC class I in the endoplasmic reticulum of DCs and mediated the trafficking of MHC class I to endolysosomal compartments for loading with exogenous peptides. We conclude that CD74 has a previously undiscovered physiological function in endolysosomal DC cross-presentation for priming MHC class I-mediated CTL responses.

引用

页码：237 / U53

页数：10

共 51 条

[1] Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens [J].