The genetics and complexity of allergy and asthma

被引：90

作者：

Barnes, KC ^{[1
]}

Marsh, DG ^{[1
]}

机构：

[1] Johns Hopkins Asthma & Allergy Ctr, Dept Med, Baltimore, MD 21224 USA

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 07期

关键词：

D O I：

10.1016/S0167-5699(97)01241-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Why do common diseases such as allergy and asthma have complex patterns of inheritance while other, relatively uncommon diseases approximate simple Mendelian traits? There is good evidence that the dysfunctioning of highly involved, interactive genetic networks is implicated in most complex diseases. Here, Kathleen Barnes and David Marsh review recent studies of asthma, which provide a good model for illustrating this point.

引用

页码：325 / 332

页数：8

共 55 条

[1] Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations [J].

Barnes, KC ;

Neely, JD ;

Duffy, DL ;

Freidhoff, LR ;

Breazeale, DR ;

Schou, C ;

Naidu, RP ;

Levett, PN ;

Renault, B ;

Kucherlapati, R ;

Iozzino, S ;

Ehrlich, E ;

Beaty, TH ;

Marsh, DG .

GENOMICS, 1996, 37 (01) :41-50

[2]

BARNES KC, IN PRESS EVOLUTIONAR

[3]

BLUMENTHAL M, 1992, J IMMUNOL, V148, P411

[4] Atopy, airway responsiveness, and genes [J].

Boguniewicz, M ;

Hayward, A .

THORAX, 1996, 51 :S55-S59

[5] ALLELE SHARING ON CHROMOSOME-11Q13 IN SIBS WITH ASTHMA AND ATOPY [J].

COLLEE, JM ;

TENKATE, LP ;

DEVRIES, HG ;

KLIPHUIS, JW ;

BOUMAN, K ;

SCHEFFER, H ;

GERRITSEN, J .

LANCET, 1993, 342 (8876) :936-936

[6] POSITIONAL CLONING MOVES FROM PERDITIONAL TO TRADITIONAL [J].

COLLINS, FS .

NATURE GENETICS, 1995, 9 (04) :347-350

[7] MATERNAL INHERITANCE OF ATOPIC IGE RESPONSIVENESS ON CHROMOSOME-11Q [J].

COOKSON, WOCM ;

YOUNG, RP ;

SANDFORD, AJ ;

MOFFATT, MF ;

SHIRAKAWA, T ;

SHARP, PA ;

FAUX, JA ;

JULIER, C ;

LESOUEF, PN ;

NAKAMURA, Y ;

LATHROP, GM ;

HOPKIN, JM .

LANCET, 1992, 340 (8816) :381-384

[8]

COOKSON WOCM, 1989, LANCET, V1, P1292

[9] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

SCIENCE, 1993, 261 (5123) :921-923

[10]

Cutting GR., 1997, EMERY RIMOINS PRINCI, P2685

← 1 2 3 4 5 6 →