The genetics and complexity of allergy and asthma

被引：90

作者：

Barnes, KC ^{[1
]}

Marsh, DG ^{[1
]}

机构：

[1] Johns Hopkins Asthma & Allergy Ctr, Dept Med, Baltimore, MD 21224 USA

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 07期

关键词：

D O I：

10.1016/S0167-5699(97)01241-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Why do common diseases such as allergy and asthma have complex patterns of inheritance while other, relatively uncommon diseases approximate simple Mendelian traits? There is good evidence that the dysfunctioning of highly involved, interactive genetic networks is implicated in most complex diseases. Here, Kathleen Barnes and David Marsh review recent studies of asthma, which provide a good model for illustrating this point.

引用

页码：325 / 332

页数：8

共 55 条

[51]

WILKINSON J, 1997, AM J RESP CRIT CARE, V155, pA257

[52]

Wills C., 1989, The wisdom of the genes: New pathways in evolution

[53] HLA-DR AND HLA-DP GENOTYPES AND IMMUNOGLOBULIN-E RESPONSES TO COMMON MAJOR ALLERGENS [J].

YOUNG, RP ;

DEKKER, JW ;

WORDSWORTH, BP ;

SCHOU, C ;

PILE, KD ;

MATTHIESEN, F ;

ROSENBERG, WMC ;

BELL, JI ;

HOPKIN, JM ;

COOKSON, WOCM .

CLINICAL AND EXPERIMENTAL ALLERGY, 1994, 24 (05) :431-439

[54] CONFIRMATION OF GENETIC-LINKAGE BETWEEN ATOPIC IGE RESPONSES AND CHROMOSOME-11Q13 [J].

YOUNG, RP ;

SHARP, PA ;

LYNCH, JR ;

FAUX, JA ;

LATHROP, GM ;

COOKSON, WOCM ;

HOPKIN, JM .

JOURNAL OF MEDICAL GENETICS, 1992, 29 (04) :236-238

[55]

ZWOLLO P, 1991, IMMUNOGENETICS, V33, P141

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