The role of cannabinoids in neurodegenerative diseases

被引:51
作者
Glass, M [1 ]
机构
[1] Univ Auckland, Dept Pharmacol, Auckland 1, New Zealand
关键词
anandamide; 2-arachidonyl-glycerol; cannabinoid Huntington's disease; marijuana; multiple sclerosis; Parkinson's disease; schizophrenia; tremor;
D O I
10.1016/S0278-5846(01)00162-2
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
1. An understanding of the actions of Cannabis (Marijuana) has evolved from folklore to science over the previous hundred years. This progression was spurred by the discovery of an endogenous cannabinoid system consisting of two receptors and two endogenous ligands. 2. This system appears to be intricately involved in normal physiology, specifically in the control of movement, formation of memories and appetite control. As we are developing an increased understanding of the physiological role of endocannabinoids it is becoming clear that they may be involved in the pathology of several neurological diseases. 3. Furthermore an array of potential therapeutic targets is being determined - including specific cannabinoid agonists and antagonists as well as compounds that interrupt the synthesis, uptake or metabolism of the endocannabinoids. 4. This article reviews the recent progress in understanding the contribution of endocannabinoids to the pathology and therapy of Huntington's disease, Parkinson's disease, schizophrenia and tremor.
引用
收藏
页码:743 / 765
页数:23
相关论文
共 119 条
[51]   The pattern of neurodegeneration in Huntington's disease:: A comparative study of cannabinoid, dopamine, adenosine and GABAA receptor alterations in the human basal ganglia in Huntington's disease [J].
Glass, M ;
Dragunow, M ;
Faull, RLM .
NEUROSCIENCE, 2000, 97 (03) :505-519
[52]   Modulation of neurotransmission by cannabinoids in the basal ganglia [J].
Glass, M ;
Brotchie, JM ;
Maneuf, YP .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (02) :199-203
[53]   Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: Evidence for a G(s) linkage to the CB1 receptor [J].
Glass, M ;
Felder, CC .
JOURNAL OF NEUROSCIENCE, 1997, 17 (14) :5327-5333
[54]  
Gonsiorek W, 2000, MOL PHARMACOL, V57, P1045
[55]   EVIDENCE FOR DEGENERATIVE AND REGENERATIVE CHANGES IN NEOSTRIATAL SPINY NEURONS IN HUNTINGTONS-DISEASE [J].
GRAVELAND, GA ;
WILLIAMS, RS ;
DIFIGLIA, M .
SCIENCE, 1985, 227 (4688) :770-773
[56]   SHORT-TERM EFFECTS OF SMOKING MARIJUANA ON BALANCE IN PATIENTS WITH MULTIPLE-SCLEROSIS AND NORMAL VOLUNTEERS [J].
GREENBERG, HS ;
WERNESS, SAS ;
PUGH, JE ;
ANDRUS, RO ;
ANDERSON, DJ ;
DOMINO, EF .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1994, 55 (03) :324-328
[57]   Cannabidiol and (-)Δ9-tetrahydrocannabinol are neuroprotective antioxidants [J].
Hampson, AJ ;
Grimaldi, M ;
Axelrod, J ;
Wink, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) :8268-8273
[58]   CHARACTERIZATION AND LOCALIZATION OF CANNABINOID RECEPTORS IN RAT-BRAIN - A QUANTITATIVE INVITRO AUTORADIOGRAPHIC STUDY [J].
HERKENHAM, M ;
LYNN, AB ;
JOHNSON, MR ;
MELVIN, LS ;
DECOSTA, BR ;
RICE, KC .
JOURNAL OF NEUROSCIENCE, 1991, 11 (02) :563-583
[59]   CANNABINOID RECEPTOR LOCALIZATION IN BRAIN [J].
HERKENHAM, M ;
LYNN, AB ;
LITTLE, MD ;
JOHNSON, MR ;
MELVIN, LS ;
DECOSTA, BR ;
RICE, KC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (05) :1932-1936
[60]   NEURONAL LOCALIZATION OF CANNABINOID RECEPTORS IN THE BASAL GANGLIA OF THE RAT [J].
HERKENHAM, M ;
LYNN, AB ;
DECOSTA, BR ;
RICHFIELD, EK .
BRAIN RESEARCH, 1991, 547 (02) :267-274