Bioactive Scaffolds for Engineering Vascularized Cardiac Tissues

被引：36

作者：

Chiu, Loraine L. Y. ^{[1
]}

Radisic, Milica ^{[1
]}

Vunjak-Novakovic, Gordana ^{[2
]}

机构：

[1] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3G9, Canada

[2] Columbia Univ, Dept Biomed Engn, New York, NY 10032 USA

来源：

MACROMOLECULAR BIOSCIENCE | 2010年 / 10卷 / 11期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院; 美国国家卫生研究院;

关键词：

biomaterial; scaffold; growth factors; angipoietin-1; VEGF; immobilization; vasculogenesis; tissue engineering; cardiac muscle; ENDOTHELIAL GROWTH-FACTOR; COVALENT INCORPORATION; MYOCARDIAL-INFARCTION; SUSTAINED DELIVERY; ALGINATE HYDROGELS; COLLAGEN MATRICES; STEM-CELLS; ANGIOPOIETIN-1; VEGF; ANGIOGENESIS;

D O I：

10.1002/mabi.201000202

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Functional vascularization is a key requirement for the development and function of most tissues, and most critically cardiac muscle. Rapid and irreversible loss of cardiomyocytes during cardiac infarction directly results from the lack of blood supply. Contractile cardiac grafts, engineered using cardiovascular cells in conjunction with biomaterial scaffolds, are an actively studied method for cardiac repair. In this article, we focus on biomaterial scaffolds designed to mediate the development and maturation of vascular networks, by immobilized growth factors. The interactive effects of multiple vasculogenic factors are discussed in the context of cardiac tissue engineering.

引用

页码：1286 / 1301

页数：16

共 92 条

[1] Surface immobilization of active vascular endothelial growth factor via a cysteine-containing tag [J].

Backer, Marina V. ;

Patel, Vimal ;

Jehning, Brian T. ;

Claffey, Kevin P. ;

Backer, Joseph M. .

BIOMATERIALS, 2006, 27 (31) :5452-5458

[2] Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium [J].

Balsam, LB ;

Wagers, AJ ;

Christensen, JL ;

Kofidis, T ;

Weissman, IL ;

Robbins, RC .

NATURE, 2004, 428 (6983) :668-673

[3] Evidence for Cardiomyocyte Renewal in Humans [J].

Bergmann, Olaf ;

Bhardwaj, Ratan D. ;

Bernard, Samuel ;

Zdunek, Sofia ;

Barnabe-Heider, Fanie ;

Walsh, Stuart ;

Zupicich, Joel ;

Alkass, Kanar ;

Buchholz, Bruce A. ;

Druid, Henrik ;

Jovinge, Stefan ;

Frisen, Jonas .

SCIENCE, 2009, 324 (5923) :98-102

[4] Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance [J].

Berry, Mark F. ;

Engler, Adam J. ;

Woo, Y. Joseph ;

Pirolli, Timothy J. ;

Bish, Lawrence T. ;

Jayasankar, Vasant ;

Morine, Kevin J. ;

Gardner, Timothy J. ;

Discher, Dennis E. ;

Sweeney, H. Lee .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2006, 290 (06) :H2196-H2203

[5] Influence of Substrate Stiffness on the Phenotype of Heart Cells [J].

Bhana, Bashir ;

Iyer, Rohin K. ;

Chen, Wen Li Kelly ;

Zhao, Ruogang ;

Sider, Krista L. ;

Likhitpanichkul, Morakot ;

Simmons, Craig A. ;

Radisic, Milica .

BIOTECHNOLOGY AND BIOENGINEERING, 2010, 105 (06) :1148-1160

[6] Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization [J].

Bogdanovic, Elena ;

Nguyen, Vicky P. K. H. ;

Dumont, Daniel J. .

JOURNAL OF CELL SCIENCE, 2006, 119 (17) :3551-3560

[7] Mechanical properties and remodeling of hybrid cardiac constructs made from heart cells, fibrin, and biodegradable, elastomeric knitted fabric [J].

Boublik, J ;

Park, H ;

Radisic, M ;

Tognana, E ;

Chen, F ;

Pei, M ;

Vunjak-Novakovic, G ;

Freed, LE .

TISSUE ENGINEERING, 2005, 11 (7-8) :1122-1132

[8] Neovascularization induced by porous collagen scaffold implanted on intact and cryoinjured rat hearts [J].

Callegari, Andrea ;

Bollini, Sveva ;

Iop, Laura ;

Chiavegato, Angela ;

Torregrossa, Gianluca ;

Pozzobon, Michela ;

Gerosa, Gino ;

De Coppi, Paolo ;

Elvassore, Nicola ;

Sartore, Saverio .

BIOMATERIALS, 2007, 28 (36) :5449-5461

[9] Direct cell adhesion to the angiopoietins mediated by integrins [J].

Carlson, TR ;

Feng, YZ ;

Maisonpierre, PC ;

Mrksich, M ;

Morla, AO .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (28) :26516-26525

[10] Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele [J].

Carmeliet, P ;

Ferreira, V ;

Breier, G ;

Pollefeyt, S ;

Kieckens, L ;

Gertsenstein, M ;

Fahrig, M ;

Vandenhoeck, A ;

Harpal, K ;

Eberhardt, C ;

Declercq, C ;

Pawling, J ;

Moons, L ;

Collen, D ;

Risau, W ;

Nagy, A .

NATURE, 1996, 380 (6573) :435-439

← 1 2 3 4 5 6 7 8 9 10 →