Modeling cortisol rhythms in a population-based study

被引：61

作者：

Ranjit, N

Young, EA

Raghunathan, TE

Kaplan, GA

机构：

[1] Univ Michigan, Sch Publ Hlth, Ctr Social Epidemiol & Populat Hlth, Dept Epidemiol, Ann Arbor, MI 48104 USA

[2] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Survey Res Ctr, Ann Arbor, MI 48109 USA

来源：

PSYCHONEUROENDOCRINOLOGY | 2005年 / 30卷 / 07期

关键词：

cortisol; diurnal profile; regression splines; mixed models;

D O I：

10.1016/j.psyneuen.2005.02.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of these analyses was to develop and describe easily implementable, yet information rich, approaches for analysis of the temporal profile of cortisol in human populations. A typical waking profile of cortisol in a sample of women aged 15-44 was parameterized by a piecewise Linear regression model, implemented as a mixed model to accommodate repeated observations among individuals. The model was extended to distinguish characteristic cortisol profiles of obese women from those of non-obese women. Sharp inflection points for the diurnal profile of cortisol were noted at 30 and 75 min past awakening. Obese women showed a slight tendency to have a less sharply rising and declining response to awakening than non-obese women. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：615 / 624

页数：10

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