Partners in crime

被引：19

作者：

Daly, MJ ^{[1
]}

Altshuler, D

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Cambridge, MA 02138 USA

[2] Broad Inst Harvard, Cambridge, MA USA

[3] MIT, Cambridge, MA 02139 USA

[4] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

来源：

NATURE GENETICS | 2005年 / 37卷 / 04期

关键词：

D O I：

10.1038/ng0405-337

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genetic culprits that contribute to common diseases remain at large, despite dedicated sleuthing by many laboratories. A new study evaluates the power of genome-wide searches for variants acting in combination, with results that are both unexpected and encouraging.

引用

页码：337 / 338

页数：2

共 14 条

[1] Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease [J].

Botstein, D ;

Risch, N .

NATURE GENETICS, 2003, 33 (Suppl 3) :228-237

[2] Multiple rare Alleles contribute to low plasma levels of HDL cholesterol [J].

Cohen, JC ;

Kiss, RS ;

Pertsemlidis, A ;

Marcel, YL ;

McPherson, R ;

Hobbs, HH .

SCIENCE, 2004, 305 (5685) :869-872

[3] New approaches to gene hunting in IBD [J].

Daly, MJ ;

Rioux, JD .

INFLAMMATORY BOWEL DISEASES, 2004, 10 (03) :312-317

[4] The inheritebasis odiabetes mellitus: Implications for the genetic analysis of complex traits [J].

Florez, JC ;

Hirschhorn, J ;

Altshuler, D .

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2003, 4 :257-291

[5] The International HapMap Project [J].

Gibbs, RA ;

Belmont, JW ;

Hardenbol, P ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Ch'ang, LY ;

Huang, W ;

Liu, B ;

Shen, Y ;

Tam, PKH ;

Tsui, LC ;

Waye, MMY ;

Wong, JTF ;

Zeng, CQ ;

Zhang, QR ;

Chee, MS ;

Galver, LM ;

Kruglyak, S ;

Murray, SS ;

Oliphant, AR ;

Montpetit, A ;

Hudson, TJ ;

Chagnon, F ;

Ferretti, V ;

Leboeuf, M ;

Phillips, MS ;

Verner, A ;

Kwok, PY ;

Duan, SH ;

Lind, DL ;

Miller, RD ;

Rice, JP ;

Saccone, NL ;

Taillon-Miller, P ;

Xiao, M ;

Nakamura, Y ;

Sekine, A ;

Sorimachi, K ;

Tanaka, T ;

Tanaka, Y ;

Tsunoda, T ;

Yoshino, E ;

Bentley, DR ;

Deloukas, P ;

Hunt, S ;

Powell, D ;

Altshuler, D ;

Gabriel, SB ;

Qiu, RZ .

NATURE, 2003, 426 (6968) :789-796

[6] Whole-genome patterns of common DNA variation in three human populations [J].

Hinds, DA ;

Stuve, LL ;

Nilsen, GB ;

Halperin, E ;

Eskin, E ;

Ballinger, DG ;

Frazer, KA ;

Cox, DR .

SCIENCE, 2005, 307 (5712) :1072-1079

[7] Editorial: Once and again - Issues surrounding replication in genetic association studies [J].

Hirschhorn, JN ;

Altshuler, D .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (10) :4438-4441

[8]

HIRSCHHORN JN, 2005, SCIENCE, V6, P95, DOI DOI 10.1038/NRG1521

[9] Mathematical multi-locus approaches to localizing complex human trait genes [J].

Hoh, J ;

Ott, J .

NATURE REVIEWS GENETICS, 2003, 4 (09) :701-709

[10] Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease [J].

Lohmueller, KE ;

Pearce, CL ;

Pike, M ;

Lander, ES ;

Hirschhorn, JN .

NATURE GENETICS, 2003, 33 (02) :177-182

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