The inheritebasis odiabetes mellitus: Implications for the genetic analysis of complex traits

被引：211

作者：

Florez, JC ^{[1
]}

Hirschhorn, J

Altshuler, D

机构：

[1] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA

[5] Whitehead MIT Ctr Genome Res, Program Med & Populat Genet, Cambridge, MA 02139 USA

[6] Childrens Hosp, Div Genet, Boston, MA 02114 USA

[7] Childrens Hosp, Div Endocrinol, Boston, MA 02114 USA

[8] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA

来源：

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS | 2003年 / 4卷

关键词：

D O I：

10.1146/annurev.genom.4.070802.110436

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Diabetes encompasses a heterogeneous group of diseases, each with a substantial genetic component. We review the division of diabetes into different subtypes based on clinical phenotype, the fruitful pursuit of genes underlying monogenic forms of the disease, the successes and drawbacks of whole-genome linkage scans in type 1 and type 2 diabetes, and the recent identification of several diabetes genes by large association studies. We use the lessons learned from this extensive body of evidence to illustrate general implications for the genetic analysis of complex traits.

引用

页码：257 / 291

页数：35

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