Predicting Harms and Benefits in Translational Trials: Ethics, Evidence, and Uncertainty

被引：66

作者：

Kimmelman, Jonathan ^{[1
]}

London, Alex John ^{[2
]}

机构：

[1] McGill Univ, Dept Social Studies Med, Biomed Ethics Unit, Montreal, PQ, Canada

[2] Carnegie Mellon Univ, Dept Philosophy, Pittsburgh, PA 15213 USA

来源：

PLOS MEDICINE | 2011年 / 8卷 / 03期

基金：

加拿大健康研究院;

关键词：

RANDOMIZED CONTROLLED-TRIAL; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; DOUBLE-BLIND; DRUG DEVELOPMENT; CLINICAL-TRIALS; CANCER; TRANSPLANTATION; STRATEGIES; DISORDERS;

D O I：

10.1371/journal.pmed.1001010

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

引用

页数：5

共 47 条

[1]

Extending Clinical Equipoise to Phase 1 Trials Involving Patients: Unresolved Problems [J].

Anderson, James A. ;

Kimmelman, Jonathan .

KENNEDY INSTITUTE OF ETHICS JOURNAL, 2010, 20 (01) :75-98

[2]

[Anonymous], 1978, The Belmont report: Ethical principles and guidelines for the protection of human subjects of research

[3]

[Anonymous], 1964, DECL HELS

[4]

Effects of NXY-059 in experimental stroke: an individual animal meta-analysis [J].

Bath, P. M. W. ;

Gray, L. J. ;

Bath, A. J. G. ;

Buchan, A. ;

Miyata, T. ;

Green, A. R. .

BRITISH JOURNAL OF PHARMACOLOGY, 2009, 157 (07) :1157-1171

[5]

*BELL HLTH INC, 2008, NEUR ANN RES TRAM AL

[6]

CHRISTIAN M, 2002, INVESTIGATORS HDB MA

[7]

Translation of highly promising basic science research into clinical applications [J].

Contopoulos-Ioannidis, DG ;

Ntzani, EE ;

Ioannidis, JPA .

AMERICAN JOURNAL OF MEDICINE, 2003, 114 (06) :477-484

[8]

What Can Be Inferred from the Interruption of the Semagacestat Trial for Treatment of Alzheimer's Disease? [J].

Cummings, Jeffrey .

BIOLOGICAL PSYCHIATRY, 2010, 68 (10) :876-878

[9]

Treatment success in cancer [J].

Djulbegovic, Berijamin ;

Kumar, Ambuj ;

Soares, Heloisa P. ;

Hozo, Iztok ;

Bepler, Gerold ;

Clarke, Mike ;

Bennett, Charles L. .

ARCHIVES OF INTERNAL MEDICINE, 2008, 168 (06) :632-642

[10]

Alzheimer's failure raises questions about disease-modifying strategies [J].

Extance, Andy .

NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (10) :749-U87

← 1 2 3 4 5 →