Innate Response Activator B Cells Protect Against Microbial Sepsis

被引：321

作者：

Rauch, Philipp J. ^{[1
,2
]}

Chudnovskiy, Aleksey ^{[1
,2
]}

Robbins, Clinton S. ^{[1
,2
]}

Weber, Georg F. ^{[1
,2
]}

Etzrodt, Martin ^{[1
,2
]}

Hilgendorf, Ingo ^{[1
,2
,8
]}

Tiglao, Elizabeth ^{[1
,2
]}

Figueiredo, Jose-Luiz ^{[1
,2
]}

Iwamoto, Yoshiko ^{[1
,2
]}

Theurl, Igor ^{[1
,2
,4
,5
,9
]}

Gorbatov, Rostic ^{[1
,2
]}

Waring, Michael T. ^{[2
,6
]}

Chicoine, Adam T. ^{[2
,6
]}

Mouded, Majd ^{[7
]}

Pittet, Mikael J. ^{[1
,2
]}

Nahrendorf, Matthias ^{[1
,2
]}

Weissleder, Ralph ^{[1
,2
,3
]}

Swirski, Filip K. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

[4] Massachusetts Gen Hosp, Program Membrane Biol, Boston, MA 02114 USA

[5] Massachusetts Gen Hosp, Div Nephrol, Boston, MA 02114 USA

[6] Massachusetts Gen Hosp, Ragon Inst Imaging Core, Boston, MA 02114 USA

[7] Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Sch Med, Pittsburgh, PA 15213 USA

[8] Univ Hosp Freiburg, Dept Cardiol, D-79106 Freiburg, Germany

[9] Univ Innsbruck Hosp, Dept Gen Internal Med Clin Immunol & Infect Dis, A-6020 Innsbruck, Austria

来源：

SCIENCE | 2012年 / 335卷 / 6068期

关键词：

COLONY-STIMULATING FACTOR; MARGINAL-ZONE; SURVIVAL; MICE; AUTOIMMUNITY; LYMPHOCYTES; CLEARANCE; ENDOTOXIN; SUBSETS; MODELS;

D O I：

10.1126/science.1215173

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recognition and clearance of a bacterial infection are fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B cells are phenotypically and functionally distinct, develop and diverge from B1a B cells, depend on pattern-recognition receptors, and produce granulocyte-macrophage colony-stimulating factor. Specific deletion of IRA B cell activity impairs bacterial clearance, elicits a cytokine storm, and precipitates septic shock. These observations enrich our understanding of innate immunity, position IRA B cells as gatekeepers of bacterial infection, and identify new treatment avenues for infectious diseases.

引用

页码：597 / 601

页数：5

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