Variation of the Glycosylation Pattern in MUC1 Glycopeptide BSA Vaccines and Its Influence on the Immune Response

被引：103

作者：

Cai, Hui ^{[2
]}

Huang, Zhi-Hua ^{[2
]}

Shi, Lei ^{[2
]}

Sun, Zhan-Yi ^{[2
]}

Zhao, Yu-Fen ^{[2
]}

Kunz, Horst ^{[1
]}

Li, Yan-Mei ^{[2
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany

[2] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 07期

关键词：

antitumor vaccines; glycopeptides; glycosylation; mucins; solid-phase peptide synthesis; SYNTHETIC ANTITUMOR VACCINES; TANDEM-REPEAT GLYCOPEPTIDE; T-CELL EPITOPE; BREAST-CANCER; INDUCTION; ANTIGENS; MUCINS; MODEL;

D O I：

10.1002/anie.201106396

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A shot in the arm for anticancer vaccines: Synthetic MUC1 glycopeptides bearing the STn and 2,6-ST antigens were conjugated covalently to BSA (see scheme). The obtained synthetic vaccines induced very strong immune responses in Balb/c mice. Predominant IgG isotype antibodies were induced. The antibodies exhibited strong binding to breast cancer cells of the MCF-7 cell line. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：1719 / 1723

页数：5

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