Cordyceps sinensis extracts do not prevent Fas-receptor and hydrogen peroxide-induced T-cell apoptosis

被引：19

作者：

Buenz, EJ

Weaver, JG

Bauer, BA

Chalpin, SD

Badley, AD ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Div Infect Dis, Rochester, MN 55905 USA

[2] Ottawa Civic Hosp, Div Gen Surg, Ottawa, ON K1Y 4E9, Canada

[3] HiHlth, Scottsdale, AZ USA

[4] Mayo Clin & Mayo Fdn, Translat Immunovirol & Biodef Program, Rochester, MN 55905 USA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 90卷 / 01期

关键词：

Cordyceps sinensis; apoptosis; reactive oxygen species; traditional medicine;

D O I：

10.1016/j.jep.2003.09.025

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Aqueous and alcohol extracts of Cordyceps sinensis (Berk) Succ. are used as a traditional medicine in China for the treatment of a wide range of diseases and are reported to have antioxidant and antiapoptotic properties. We therefore examined the ability of aqueous, organic, and alcohol extracts of Cordyceps sinensis to inhibit apoptosis induced either by hydrogen peroxide or Fas-receptor ligation; both stimuli induce apoptosis dependent on reactive oxygen species. Cells pre-incubated with Cordyceps sinensis extracts were equally sensitive to hydrogen peroxide and Fas-mediated apoptosis. Thus, the putative antioxidant and antiapoptotic properties of Cordyceps sinensis are insufficient to rescue cells from apoptosis induced by these stimuli in vitro. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：57 / 62

页数：6

共 48 条

[1] Cellular titration of apoptosis with steady state concentrations of H2O2:: Submicromolar levels of H2O2 induce apoptosis through Fenton chemistry independent of the cellular thiol state [J].