Cardiac sodium channel Markov model with temperature dependence and recovery from inactivation

被引:52
作者
Irvine, LA [1 ]
Jafri, MS [1 ]
Winslow, RL [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Ctr Computat Med & Biol, Baltimore, MD 21205 USA
关键词
D O I
10.1016/S0006-3495(99)77346-7
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
A Markov model of the cardiac sodium channel is presented. The model is similar to the CA1 hippocampal neuron sodium channel model developed by Kuo and Bean (1994. Neuron. 12:819-829) with the following modifications: 1) an additional open state is added; 2) open-inactivated transitions are made voltage-dependent; and 3) channel rate constants are exponential function of enthalpy, entropy, and voltage and have explicit temperature dependence. Model parameters are determined using a simulated annealing algorithm to minimize the error between model responses and various experimental data sets.:The model reproduces a wide range of experimental data including ionic currents, gating currents, tail currents, steady-state inactivation, recovery from inactivation, and open time distributions over a temperature range of 10 degrees C to 25 degrees C. The model also predicts measures of single channel activity such as first latency, probability of a null sweep, and probability of reopening.
引用
收藏
页码:1868 / 1885
页数:18
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