Perivascular nitric oxide gradients normalize tumor vasculature

被引：136

作者：

Kashiwagi, Satoshi ^{[1
,3
]}

Tsukada, Kosuke ^{[1
,3
]}

Xu, Lei ^{[1
,3
]}

Miyazaki, Junichi ^{[1
,3
]}

Kozin, Sergey V. ^{[1
,3
]}

Tyrrell, James A. ^{[1
,3
]}

Sessa, William C. ^{[2
]}

Gerweck, Leo E. ^{[1
,3
]}

Jain, Rakesh K. ^{[1
,3
]}

Fukumura, Dai ^{[1
,3
]}

机构：

[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA

[2] Yale Univ, Sch Med, Dept Pharmacol, Boyer Ctr Mol Med, New Haven, CT 06536 USA

[3] Harvard Univ, Sch Med, Boston, MA 02114 USA

来源：

NATURE MEDICINE | 2008年 / 14卷 / 03期

关键词：

D O I：

10.1038/nm1730

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.

引用

收藏

页码：255 / 257

页数：3

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