The role of nitric oxide in tumour progression

被引：1039

作者：

Fukumura, Dai ^{[1
]}

Kashiwagi, Satoshi

Jain, Rakesh K.

机构：

[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 07期

关键词：

D O I：

10.1038/nrc1910

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are known to exert both pro- and anti-tumour effects. We summarize our current understanding of the role of NO in tumour progression, especially in relation to angiogenesis and vascular functions. We also discuss potential strategies for cancer treatment that modulate NO production and/or its downstream signalling pathways.

引用

页码：521 / 534

页数：14

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