The role of nitric oxide in tumour progression

被引：1039

作者：

Fukumura, Dai ^{[1
]}

Kashiwagi, Satoshi

Jain, Rakesh K.

机构：

[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 07期

关键词：

D O I：

10.1038/nrc1910

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are known to exert both pro- and anti-tumour effects. We summarize our current understanding of the role of NO in tumour progression, especially in relation to angiogenesis and vascular functions. We also discuss potential strategies for cancer treatment that modulate NO production and/or its downstream signalling pathways.

引用

页码：521 / 534

页数：14

共 172 条

[41] ANTIMETASTATIC EFFECTS ASSOCIATED WITH PLATELET REDUCTION [J].

GASIC, GJ ;

GASIC, TB ;

STEWART, CC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1968, 61 (01) :46-&

[42] Tumour-derived and host-derived nitric oxide differentially regulate breast carcinoma metastasis to the lungs [J].

Gauthier, N ;

Lohm, S ;

Touzery, C ;

Chantôme, A ;

Perette, B ;

Reveneau, S ;

Brunotte, F ;

Juillerat-Jeanneret, L ;

Jeannin, JF .

CARCINOGENESIS, 2004, 25 (09) :1559-1565

[43] Nitric oxide affects the production of reactive oxygen species in hepatoma cells: Implications for the process of oxygen sensing [J].

Genius, J ;

Fandrey, J .

FREE RADICAL BIOLOGY AND MEDICINE, 2000, 29 (06) :515-521

[44] Biological significance of nitric oxide-mediated protein modifications [J].

Gow, AJ ;

Farkouh, CR ;

Munson, DA ;

Posencheg, MA ;

Ischiropoulos, H .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2004, 287 (02) :L262-L268

[45] Caveolae and caveolins in the cardiovascular system [J].

Gratton, JP ;

Bernatchez, P ;

Sessa, WC .

CIRCULATION RESEARCH, 2004, 94 (11) :1408-1417

[46] Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice [J].

Gratton, JP ;

Lin, MI ;

Yu, J ;

Weiss, ED ;

Jiang, ZJ ;

Fairchild, TA ;

Iwakiri, Y ;

Groszmann, R ;

Claffey, KP ;

Cheng, YC ;

Sessa, WC .

CANCER CELL, 2003, 4 (01) :31-39

[47] S-nitrosylation of matrix metalloproteinases: Signaling pathway to neuronal cell death [J].

Gu, ZZ ;

Kaul, M ;

Yan, BX ;

Kridel, SJ ;

Cui, JK ;

Strongin, A ;

Smith, JW ;

Liddington, RC ;

Lipton, SA .

SCIENCE, 2002, 297 (5584) :1186-1190

[48] Molecular regulation of microlymphatic formation and function: Role of nitric oxide [J].

Hagendoorn, J ;

Padera, TP ;

Fukumura, D ;

Jain, RK .

TRENDS IN CARDIOVASCULAR MEDICINE, 2005, 15 (05) :169-173

[49] Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics [J].

Hagendoorn, J ;

Padera, TP ;

Kashiwagi, S ;

Isaka, N ;

Noda, F ;

Lin, MI ;

Huang, PL ;

Sessa, WC ;

Fukumura, D ;

Jain, RK .

CIRCULATION RESEARCH, 2004, 95 (02) :204-209

[50] Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion [J].

Harmey, JH ;

Bucana, CD ;

Lu, WX ;

Byrne, AM ;

McDonnell, S ;

Lynch, C ;

Bouchier-Hayes, D ;

Dong, ZY .

INTERNATIONAL JOURNAL OF CANCER, 2002, 101 (05) :415-422

← 1 2 3 4 5 6 7 8 9 10 →