Phenylpiperazine derivatives with strong affinity for 5HT1A, D2A and D3 receptors

被引：30

作者：

Terán, C

Santana, L ^{[1
]}

Uriarte, E

Fall, Y

Unelius, L

Tolf, BR

机构：

[1] Univ Santiago, Fac Pharm, Dept Organ Chem, E-15706 Santiago, Spain

[2] Univ Vigo, Dept Phys Chem & Organ Chem, Vigo 36200, Spain

[3] Astra Arcus AB, Preclin Res & Dev, S-15185 Sodertalje, Sweden

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(98)00646-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four 7-[3-(4-phenyl-1-piperazinyl)propoxy]coumarins were synthesized. The affinities of these compounds for DA (D-2A, D-3) and 5HT(1A) receptors were evaluated for their ability to displace [H-3]-raclopride and [H-3]-8-OH-DPAT respectively from their specific binding sites. The affinities of the target compounds were all in the nanomolar range and followed the order 5-HT1A > D-2 > D-3 (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：3567 / 3570

页数：4

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