Biochemical Modulation of the Sleep-Wake Cycle: Endogenous Sleep-Inducing Factors

被引：21

作者：

Arias-Carrion, Oscar ^{[2
]}

Huitron-Resendiz, Salvador ^{[3
]}

Arankowsky-Sandoval, Gloria ^{[4
]}

Murillo-Rodriguez, Eric ^{[1
]}

机构：

[1] Univ Anahuac Mayab, Lab Neurociencias Mol & Integrativas, Escuela Med, Div Ciencias Salud, Merida 97310, Yucatan, Mexico

[2] Univ Marburg, Dept Neurol, Marburg, Germany

[3] Scripps Res Inst, Mol & Integrat Neurosci Dept, San Diego, CA USA

[4] Univ Autonoma Yucatan, Neurobiol Lab, Dept Neurociencias, Ctr Invest Region Dr Hideyo Noguchi, Merida 97310, Yucatan, Mexico

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2011年 / 89卷 / 08期

关键词：

sleep-wake cycle; neurotransmitter; brainstem; anandamide; lateral hypothalamus; cortex; PROSTAGLANDIN-D SYNTHASE; CB1 CANNABINOID RECEPTOR; EYE-MOVEMENT SLEEP; HORMONE-RELEASING-HORMONE; MESSENGER-RNA; UROTENSIN-II; ACETYLCHOLINE-RELEASE; BASAL FOREBRAIN; ADENOSINE A(1); RAT-BRAIN;

D O I：

10.1002/jnr.22666

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Regulation of the sleep-wake cycle involves diverse brain circuits and molecules. Further complexity has been introduced by the recognition of sleep-promoting factors that accumulate in the brain naturally or during prolonged waking. The variety of sleep-inducing molecules includes peptides, cytokines, and lipids. With regard to the lipids, current evidence indicates the existence of endogenous lipids, called endocannabinoids, that mimic the pharmacological actions of the psychoactive ingredient of marijuana and that are likely to be essential factors in sleep promotion. This Mini-Review presents current knowledge concerning the role of endogenous compounds with sleep-promoting properties. (C) 2011 Wiley-Liss, Inc.

引用

页码：1143 / 1149

页数：7

共 90 条

[1]

Cannabinoid CB1 receptor agonists increase rat cortical and hippocampal acetylcholine release in vivo [J].