CSF prostaglandin D synthase is reduced in excessive daytime sleepiness

被引：15

作者：

Bassetti, Claudio L.

Hersberger, Martin

Baumann, Christian R.

机构：

[1] Univ Spital Zurich, Inst Clin Chem, Zurich, Switzerland

[2] Univ Spital Zurich, Dept Neurol, CH-8091 Zurich, Switzerland

来源：

JOURNAL OF NEUROLOGY | 2006年 / 253卷 / 08期

关键词：

hypersomnia; excessive daytime sleepiness; prostaglandin; betatrace; sleep; narcolepsy;

D O I：

10.1007/s00415-006-0153-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Lipocalin-type prostaglandin D synthase (L-PGDS) is a brain enzyme, which produces prostaglandin D-2, a substance with endogenous somnogenic effects. Using a standardized protocol for immunonephelometric determination of cerebrospinal fluid (CSF) L-PGDS levels, we show that CSF L-PGDS levels are significantly lower in 34 patients with excessive daytime sleepiness when compared with levels in 22 healthy controls. Thus, L-PGDS may represent the first neurochemical measure of excessive daytime sleepiness.

引用

收藏

页码：1030 / 1033

页数：4

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