Utility of boron clusters for drug design.: Hansch-Fujita hydrophobic parameters π of dicarba-closo-dodecaboranyl groups

被引：71

作者：

Yamamoto, K ^{[1
]}

Endo, Y ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(01)00438-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The spherical boron clusters, dicarba-closo-dodecaboranes (carboranes) are new hydrophobic pharmacophores, which interact hydrophobically with receptors. We have experimentally measured the partition coefficients log P for carboranylphenols employing an HPLC method, and determined the Hansch Fujita hydrophobic parameters pi of various carboranyl groups. The values (pi = 2.69-4.44) vary depending on the position of substitution on the carborane cage and the isomeric form (o-, m-, p-carboranes). These values lie within the range of those of hydrocarbons. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2389 / 2392

页数：4

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