High signal to noise ratio in low field NMR on chip, simulations and experimental results.

被引：19

作者：

Wensink, H ^{[1
]}

Hermes, DC ^{[1
]}

van den Berg, A ^{[1
]}

机构：

[1] Univ Twente, MESA Inst Nanotechnol, BIOS Lab Chip Grp, NL-7500 AE Enschede, Netherlands

来源：

MEMS 2004: 17TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, TECHNICAL DIGEST | 2004年

关键词：

D O I：

10.1109/MEMS.2004.1290608

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

A mufluidic chip with integrated microcoil was developed for Nuclear Magnetic Resonance (NMR) spectroscopy on limited volume samples (nanoliters range). This chip will be used for the online monitoring of micro chemical reactions. Design rules for the microcoil to achieve the best Signal to Noise Ratio (SNR) were obtained by finite element simulation. For pure water in a low field NMR magnet (60 MHz i.e. 1.4 Tesla) a SNR of 550 was achieved which is to our knowledge higher than any other mufluidic chip with integrated detection coil. It is also shown that a spectral resolution of 0.025 ppm is obtained when a microchannet with an arbitrary cross section is placed parallel to the magnetic field. A high SNR at low magnetic field for small volume samples is essential for the development of portable NMR systems where mini permanent magnets of 1 Tesla are used.

引用

页码：407 / 410

页数：4

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