Computation with the KEGG pathway database

被引：200

作者：

Ogata, H ^{[1
]}

Goto, S ^{[1
]}

Fujibuchi, W ^{[1
]}

Kanehisa, M ^{[1
]}

机构：

[1] Kyoto Univ, Inst Chem Res, Uji, Kyoto 611, Japan

来源：

BIOSYSTEMS | 1998年 / 47卷 / 1-2期

关键词：

pathway reconstruction; pathway comparison; sequence analysis; gene organisation in the genome;

D O I：

10.1016/S0303-2647(98)00017-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We introduce and discuss a new computational approach towards prediction and inference of biological functions from genomic sequences by making use of the pathway data in KEGG. Due to its piecewise nature, the current approach of predicting each gene function based on sequence similarity searches often fails to reconstruct cellular functions with all necessary components. The pathway diagram in KEGG, which may be considered a wiring diagram of molecules in biological systems, can be utilised as a reference for functional reconstruction. KEGG also contains binary relations that represent molecular interactions and relations and that can be utilised for computing and comparing pathways. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：119 / 128

页数：10

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