Role of the subthalamo-nigral input in the control of amygdala-kindled seizures in the rat

被引：58

作者：

Deransart, C ^{[1
]}

Lê, BT ^{[1
]}

Marescaux, C ^{[1
]}

Depaulis, A ^{[1
]}

机构：

[1] Fac Med Strasbourg, INSERM, U398, F-67085 Strasbourg, France

来源：

BRAIN RESEARCH | 1998年 / 807卷 / 1-2期

关键词：

epilepsy; amygdala kindled seizure; basal ganglia; substantia nigra pars reticulata; subthalamic nucleus;

D O I：

10.1016/S0006-8993(98)00745-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The substantia nigra pars reticulate (SNpr) is a critical site for the control of epileptic seizures. Potentiation of the inhibitory GABAergic input from the striatum to the SNpr suppresses primary or secondary generalized seizures in the rat. The purpose of this study was to examine the possible involvement of the excitatory glutamatergic input from the subthalamic nucleus to the SNpr in the control of both the electroencephalographic and the motor components of amygdala-kindled seizures in the rat. Microinjections of either an N-methyl-D-aspartate (NMDA) antagonist in the substantia nigra or a GABA(A) agonist in the subthalamic nucleus, significantly reduced motor seizures but did not modified the afterdischarges. These results provide evidence for the involvement of the subthalamo-nigral projection in the modulation and the propagation of the motor components of amygdala-kindled seizures. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：78 / 83

页数：6

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