Elevations of amniotic fluid macrophage inflammatory protein-1 alpha concentrations in women during term and preterm labor

被引:56
作者
Dudley, DJ [1 ]
Hunter, C [1 ]
Mitchell, MD [1 ]
Varner, MW [1 ]
机构
[1] UNIV AUCKLAND,DEPT PHARMACOL & CLIN PHARMACOL,AUCKLAND,NEW ZEALAND
关键词
D O I
10.1016/0029-7844(95)00366-5
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To determine whether elevated concentrations of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in amniotic fluid (AF) are related to term and preterm labor. Methods: Amniotic fluid was obtained from women from five different clinical situations: 1) term cesarean delivery, no labor (n = 29); 2) normal term labor, no infection (n = 36); 3) preterm labor, delivery more than 1 week from sampling, no infection (n = 19); 4) preterm labor, delivery within 1 week from sampling, no infection (n = 18); and 5) preterm chorioamnionitis (n = 8). Amniotic fluid was collected aseptically at the time of amniocentesis, amniotomy, or hysterotomy. Concentrations of MIP-1 alpha were determined by enzyme-linked immunosorbent assay. Statistical analysis was by Wilcoxon rank-sum test, Kruskal-Wallis test, and unpaired t test. Results: Women in normal term labor had significant elevations of AF MIP-1 alpha concentrations when compared with women at term undergoing repeat cesarean delivery (P <.001). In women with term gestation, AF MIP-1 alpha correlated well with cervical dilation (r(2) = 0.479, P <.001). In women with preterm labor who later delivered within 1 week of presentation, AF MIP-1 alpha concentrations were higher than those from women who did not deliver within 1 week. Women who presented with clinically evident chorioamnionitis had the highest concentrations of AF MIP-1 alpha (P =.001). Conclusion: Women in labor have significantly elevated AF concentrations of MIF-1 alpha, particularly if labor is associated with intrauterine infection. We suggest that MIP-1 alpha is involved in the physiology of normal labor and in the pathogenesis of infection-associated preterm labor.
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页码:94 / 98
页数:5
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