REGULATION OF HUMAN DECIDUAL CELL MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA (MIP-1-ALPHA) PRODUCTION BY INFLAMMATORY CYTOKINES

被引:41
作者
DUDLEY, DJ [1 ]
SPENCER, S [1 ]
EDWIN, S [1 ]
MITCHELL, MD [1 ]
机构
[1] UNIV AUCKLAND,DEPT PHARMACOL & CLIN PHARMACOL,AUCKLAND,NEW ZEALAND
来源
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1995年 / 34卷 / 04期
关键词
DECIDUAL CELLS; MIP-1-ALPHA; PRETERM LABOR; CHEMOKINES;
D O I
10.1111/j.1600-0897.1995.tb00946.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
PROBLEM: Inflammation of human gestational tissues is a key pathophysiologic event in the genesis of infection-associated preterm labor. Human gestational tissues produce several inflammatory cytokines after stimulation with bacterial products. These include interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha), and IL-6. Another class of cytokines includes chemokines of the ''C-C'' subclassification such as macrophage inflammatory protein-1 alpha (MIP-1 alpha). The purpose of this study was to determine whether cultured human decidual cells produce MIP-la: in response to other inflammatory cytokines. METHODS: Various concentrations of IL-1 beta, TNF alpha, IL-6, and IL-4 were incubated with confluent monolayer cultures of decidual cells isolated from normal term placentae for 16 h at 37 degrees C, and MIP-1 alpha concentrations in culture supernatants were measured by ELISA. RESULTS: We found that incubation of decidual cells with IL-1 beta, TNF alpha, and IL-4 resulted in significant concentration-dependent increases in MIP-1 alpha production. IL-6 had no effect on MIP-1 alpha production. CONCLUSIONS: Our data are the first to show that human decidual cells in culture produce MIP-1 alpha in response to other inflammatory cytokines. We suggest that decidual cell production of MIP-1 alpha is an important early event in the pathophysiology of infection-associated preterm labor.
引用
收藏
页码:231 / 235
页数:5
相关论文
共 27 条
  • [1] ACTIONS OF INTERLEUKIN-4 ON PROSTAGLANDIN BIOSYNTHESIS AT THE CHORION-DECIDUAL INTERFACE
    ADAMSON, S
    EDWIN, SS
    LAMARCHE, S
    MITCHELL, MD
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1993, 169 (06) : 1442 - 1447
  • [2] INTERLEUKIN-6 IN BIOLOGY AND MEDICINE
    AKIRA, S
    TAGA, T
    KISHIMOTO, T
    [J]. ADVANCES IN IMMUNOLOGY, VOL 54, 1993, 54 : 1 - 78
  • [3] BAGGIOLINI M, 1994, ADV IMMUNOL, V55, P97
  • [4] CACHECTIN TUMOR NECROSIS FACTOR-ALPHA FORMATION IN HUMAN DECIDUA - POTENTIAL ROLE OF CYTOKINES IN INFECTION-INDUCED PRETERM LABOR
    CASEY, ML
    COX, SM
    BEUTLER, B
    MILEWICH, L
    MACDONALD, PC
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (02) : 430 - 436
  • [5] NEUTROPHIL ATTRACTANT ACTIVATING PEPTIDE-1 INTERLEUKIN-8 - ASSOCIATION WITH HISTOLOGIC CHORIOAMNIONITIS, PRETERM DELIVERY, AND BIOACTIVE AMNIOTIC-FLUID LEUKOATTRACTANTS
    CHEROUNY, PH
    PANKUCH, GA
    ROMERO, R
    BOTTI, JJ
    KUHN, DC
    DEMERS, LM
    APPELBAUM, PC
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1993, 169 (05) : 1299 - 1303
  • [6] DEVLIN EE, 1985, J CLIN ENDOCR METAB, V60, P880
  • [7] BIOSYNTHESIS OF INTERLEUKIN-6 BY CULTURED HUMAN CHORION LAEVE CELLS - REGULATION BY CYTOKINES
    DUDLEY, DJ
    TRAUTMAN, MS
    EDWIN, SS
    LUNDINSCHILLER, S
    MITCHELL, MD
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 75 (04) : 1081 - 1086
  • [8] INFLAMMATORY MEDIATORS REGULATE INTERLEUKIN-8 PRODUCTION BY CULTURED GESTATIONAL TISSUES - EVIDENCE FOR A CYTOKINE NETWORK AT THE CHORIO-DECIDUAL INTERFACE
    DUDLEY, DJ
    TRAUTMAN, MS
    MITCHELL, MD
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 76 (02) : 404 - 410
  • [9] CLINICAL-VALUE OF AMNIOTIC-FLUID INTERLEUKIN-6 DETERMINATIONS IN THE MANAGEMENT OF PRETERM LABOR
    DUDLEY, DJ
    HUNTER, C
    MITCHELL, MD
    VARNER, MW
    [J]. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1994, 101 (07): : 592 - 597
  • [10] DUDLEY DJ, 1991, J CLIN ENDOCR METAB, V74, P884